Self-assembly of F0F1-ATPase motors and ghost.
Self-assembly of F0F1-ATPase motors and ghost.
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DOI：
10.1021/la804083f
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发表时间：
2009-04
期刊：
影响因子：
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通讯作者：
Ning Tao;Jie Cheng;Ling Wei;J. Yue
中科院分区：
文献类型：
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作者：
Ning Tao;Jie Cheng;Ling Wei;J. Yue
F0 F1-ATP酶马达具有独特的机械性能，使其成为纳米技术领域有吸引力的构建模块。然而，如何将其组织成具有实际职能的明确结构，仍然是一项重大挑战。在这里，我们描述了一个自组装复合物形成的F0 F1-ATP酶和鬼这是有序的。复合物的形成包括两个步骤：分子马达首先自组装成细丝，然后附着在幽灵上。幽灵和附着的细丝然后聚集成大的自组装复合物。在光照下，这些复合物由于分子马达的旋转力而分解。复合物是宏观的，具有大于1 mm的直径。这种柔性生物材料（幽灵）与动态生物材料（F0 F1-ATP酶分子马达）自组装的复合物具有几个优点，包括柔性、稳定性和受光控制的能力，并且可以用作可控旋转分子机器。
F0F1-ATPase motors have unique mechanical properties, making them attractive building blocks in the field of nanotechnology. However, their organization into well-defined structures with practical functions remains a critical challenge. Here, we describe a self-assembling complex formed by F0F1-ATPase and a ghost which is ordered. Formation of the complex includes two steps: the molecular motors first self-assemble into filaments and then attach to the ghost. The ghost and attached filaments then aggregate into large self-assembled complexes. On illumination, these complexes disassemble because of the rotation force of the molecular motors. The complexes are macroscopic, having a diameter greater than 1 mm. Such complexes of a flexible biomaterial (ghost) self-assembled with a dynamic biomaterial (F0F1-ATPase molecular motor) have several advantages, including flexibility, stability, and ability to be controlled by light, and could be used as controllable rotational molecular machines.