Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.
Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.
复制标题
抗肿瘤剂。
DOI：
10.1016/j.bmcl.2003.12.096
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Lee,Kuo-Hsiung
中科院分区：
文献类型：
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作者：
Xiao,Zhiyan;Han,Shiqing;Bastow,KennethF;Lee,Kuo-Hsiung
以鬼臼毒素为原料，经6步合成了11,13-O,O ' -环亚硫酸盐GL-331类似物(7)，并被评价为潜在的抗肿瘤药物。化合物7对人肿瘤细胞系有明显的细胞毒性，但对人DNA拓扑异构酶II无抑制作用。该化合物代表了抗肿瘤鬼臼毒素类似物的新原型。
An 11,13-O,O′-cyclosulfite GL-331 analogue (7) was synthesized in six steps from podophyllotoxin and evaluated as a potential antitumor agent. Compound 7 was significantly cytotoxic against human tumor cell lines, but showed no inhibition against human DNA topoisomerase II in vitro. This compound represents a novel prototype of antitumor podophyllotoxin analogues.