Herpes simplex encephalitis and subsequent cytomegalovirus encephalitis after chemoradiotherapy for central nervous system lymphoma: a case report and literature review
Herpes simplex encephalitis and subsequent cytomegalovirus encephalitis after chemoradiotherapy for central nervous system lymphoma: a case report and literature review
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中枢神经系统淋巴瘤放化疗后并发单纯疱疹脑炎及继发巨细胞病毒脑炎一例报告及文献复习
DOI：
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发表时间：
2008
影响因子：
2.1
通讯作者：
M. Kurokawa
中科院分区：
文献类型：
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作者：
Hiroshi I. Suzuki;A. Hangaishi;N. Hosoya;Takuro Watanabe;Y. Kanda;T. Motokura;S. Chiba;M. Kurokawa
恶性血液病治疗过程中的神经系统并发症有多种原因。治疗相关性白质脑病已被认为是中枢神经系统（CNS）淋巴瘤联合化疗和放疗的主要并发症，并可能使CNS感染的诊断复杂化。在此，我们报告一位弥漫性大B细胞淋巴瘤患者，在接受化疗及放射治疗后，发生单纯疱疹病毒性脑炎及巨细胞病毒性脑炎。虽然脑脊液检查（CSF）显示没有显着的白细胞增多症，脑磁共振成像和聚合酶链反应分析的CSF是有用的诊断。通过对HSE与CNS恶性肿瘤放射治疗相关性的文献回顾，我们的病例表明，在CNS淋巴瘤放化疗期间，对病毒性脑炎的认识在急性神经功能障碍的鉴别诊断中非常重要。
Neurological complications during the treatment of hematological malignancies have a wide range of causes. Treatment-related leukoencephalopathy has been recognized as a major complication of combined chemotherapy and radiotherapy for central nervous system (CNS) lymphoma, and can complicate the diagnosis of CNS infection. Herein, we present a patient with diffuse large B-cell lymphoma who developed herpes simplex encephalitis (HSE) and subsequent cytomegalovirus encephalitis after chemoradiotherapy for CNS relapse. Although cerebrospinal fluid examination (CSF) showed no significant pleocytosis, brain magnetic resonance imaging and polymerase chain reaction analysis of the CSF were useful in the diagnosis. With a review of the literature on the association between HSE and radiotherapy for CNS malignancies, our case suggests that an awareness of viral encephalitis is important in the differential diagnosis of acute neurologic disturbance during chemoradiotherapy for CNS lymphoma.
影响因子：
45.3
作者：
DeAngelis, LM;Seiferheld, W;Schultz, CJ
通讯作者：
Schultz, CJ