Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma
Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma
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DOI：
10.1111/j.1440-1746.2004.03348.x
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发表时间：
2004-06-01
影响因子：
4.1
通讯作者：
Kim, JS
中科院分区：
文献类型：
--
作者：
Byeon, JS;Jung, HY;Kim, JS
背景资料：血管内皮生长因子-C（VEGF-C）是一种特异性的肿瘤生长因子，在多种恶性肿瘤的生长、淋巴结转移和远处器官转移中发挥一定作用。本研究的目的是研究VEGF-C在人食管鳞状细胞癌（ESCC）中的表达，以阐明其在肿瘤进展和淋巴结转移中的作用。方法：应用免疫组化SP法检测13例食管鳞癌内镜切除标本和21例手术切除标本中VEGF-C和考克斯-2的表达，并分析其与食管鳞癌发生发展的关系。结果：VEGF-C的表达随肿瘤深度的增加而增加（r = 0.521，P = 0.002），随肿瘤分期的增加而增加（r = 0.572，P < 0.001），考克斯-2的表达随肿瘤深度的增加而增加（r = 0.387，P = 0.024）。VEGF-C阳性率在术前认为无区域淋巴结转移的早期癌和术后证实有区域淋巴结转移的晚期癌之间存在差异（20.0% vs 100.0%; P < 0.001）。食管鳞癌组织中VEGF-C的表达与考克斯-2的表达有关，VEGF-C的表达还与原发肿瘤的深度、分期及淋巴结转移有关。因此，VEGF-C在食管鳞癌中表达的研究可能有助于管理计划。(C)2004年Blackwell Publishing Asia Pty Ltd.
Background: Vascular endothelial growth factor-C (VEGF-C) is a specific growth factor of lymphatics, which is known to play some role in tumor growth and metastasis to lymph nodes and distant organs in various malignancies. The purpose of the present study was to investigate the expression of VEGF-C in human esophageal squamous cell carcinomas (ESCC) to elucidate its role in tumor progression and lymph node metastasis. Another aim of the study was to investigate the relation between VEGF-C and cyclooxygenase-2 (COX-2) in ESCC.Methods: The expression of VEGF-C and COX-2 in ESCC was evaluated in 13 endoscopic mucosal resection specimens and in 21 surgical specimens by immunohistochemical staining. Clinical data were obtained from medical records.Results: The degree of VEGF-C expression increased as the depth of primary tumor progressed (r = 0.521, P = 0.002), the stage progressed (r = 0.572, P < 0.001), and the degree of COX-2 expression increased (r = 0.387, P = 0.024). The VEGF-C positive rate was different between early cancers in which regional lymph node metastasis was thought to be absent and advanced cancers in which regional lymph node metastases were confirmed after surgery (20.0% vs 100.0%; P < 0.001).Conclusions: The VEGF-C expression in ESCC is related to COX-2 expression, and VEGF-C is also associated with the depth of primary tumor, the stage, and probably lymph node metastasis. Thus the investigation of VEGF-C expression in ESCC may assist in management planning. (C) 2004 Blackwell Publishing Asia Pty Ltd.