DYSLIPIDEMIA IN PREGNANCY MAY CONTRIBUTE TO INCREASED RISK OF NEURAL TUBE DEFECTS -A PILOT STUDY IN NORTH INDIAN POPULATION
DYSLIPIDEMIA IN PREGNANCY MAY CONTRIBUTE TO INCREASED RISK OF NEURAL TUBE DEFECTS -A PILOT STUDY IN NORTH INDIAN POPULATION
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DOI：
10.1007/s12291-009-0027-9
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发表时间：
2009-04-01
影响因子：
2.1
通讯作者：
Singh, Ritu
中科院分区：
文献类型：
--
作者：
Gupta, Supriya;Arora, Sarika;Singh, Ritu
神经管缺陷是由于神经管闭合不当或不及时导致的大脑和脊柱先天性结构异常。据报道，患有糖尿病和肥胖症的女性神经管缺陷的患病率较高。本研究旨在探讨产前患者血脂异常与胎儿神经管缺陷风险之间的关系。本研究是一项观察性横断面研究，涉及 129 名妊娠期 16 至 18 周的孕妇。其中，80 名女性正常妊娠，49 名女性为神经管缺陷临床高危病例。通过酶测定法分析空腹血样的血糖和血脂谱，并使用酶免疫测定法分析甲胎蛋白水平。甲胎蛋白 (AFP) 值转换为适合胎龄的中位数倍数 (MoM)。根据 AFP 值，女性被标记为筛查阴性（AFP 2 MoM，n =27）。筛查结果呈阳性的女性通过超声进一步评估，发现 21 名女性携带神经管缺陷阳性妊娠。在SPSS软件上进行统计分析。女性体重与血清甘油三酯、血浆糖和AFP MoM值呈显着正相关。正常女性与神经管缺陷阳性妊娠女性之间的血清胆固醇水平（p=0.038）、甘油三酯（p=0.001）和血浆糖水平（p=0.002）存在显着差异。血脂异常病例中神经管缺陷风险的优势比为 24.23 (CI 4.73 - 148.60)，相对风险为 12.12。研究发现血脂异常尤其是高甘油三酯血症与胎儿神经管缺陷显着相关。
Neural tube defects are congenital structural abnormalities of the brain and vertebral column resulting from improper or non- timely closure of the neural tube. Prevalence of neural tube defects is reported to be higher among women with diabetes mellitus and obesity. This study was designed to investigate the relation between the presence of dyslipidemia in antenatal patients and the risk of fetal neural tube defects. The present study was an observational, cross- sectional study involving 129 pregnant women in 16 to 18 weeks gestation period. Of these, 80 women had normal pregnancies and 49 were clinically high- risk cases for neural tube defects. Fasting blood samples were analyzed for blood sugar and lipid profile by enzymatic assay and alpha- fetoprotein levels using Enzyme Immunoassay. Alpha- fetoprotein (AFP) values were converted to Multiples of Median (MoM) appropriate for the gestational age. Based on AFP values, women were labeled as screen negative (AFP 2 MoM, n =27). Screen positive women were further evaluated by ultrasound and 21 women were found to carry a neural tube defects positive pregnancy. Statistical analysis was done on SPSS software. Body weight of the women showed a significant positive correlation with serum triglycerides, plasma sugar and AFP MoM values. A significant difference was observed in serum cholesterol levels (p= 0.038), triglycerides (p= 0.001) and plasma sugar levels (p=0.002) between normal women and those with neural tube defects positive pregnancy. The Odds ratio for neural tube defects risk in dyslipidemic cases was 24.23 (CI 4.73 - 148.60) with a relative risk of 12.12. Dyslipidemia especially hypertriglyceridemia was found to be significantly associated with fetal neural tube defects.