Mapping of unconventional myosins in mouse and human
Mapping of unconventional myosins in mouse and human
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DOI：
10.1006/geno.1996.0488
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发表时间：
1996-09-15
期刊：
影响因子：
4.4
通讯作者：
Jenkins, NA
中科院分区：
文献类型：
--
作者：
Hasson, T;Skowron, JF;Jenkins, NA
肌球蛋白是沿着丝状肌动蛋白运动的分子马达。在脊椎动物中表达七种类型的肌球蛋白：常规肌球蛋白或肌球蛋白-II，以及6种非常规肌球蛋白类型-I、-V、-VI、VII、-IX和-X。我们已经在小鼠中绘制了22个探针，包括所有已知的非常规肌球蛋白，因此，已经确定了16个潜在的非常规肌球蛋白基因。这些基因包括7个肌球蛋白-I、2个肌球蛋白-V、1个肌球蛋白-VI、3个肌球蛋白-VII、2个肌球蛋白-IX和1个肌球蛋白-X。通过荧光原位杂交确定了其中5个基因在人类染色体中的图谱位置。(C)出版社：Academic Press，Inc.
Myosins are molecular motors that move along filamentous actin. Seven classes of myosin are expressed in vertebrates: conventional myosin, or myosin-II, as well as the 6 unconventional myosin classes -I, -V, -VI, VII, -IX, and -X. We have mapped in mouse 22 probes encompassing all known unconventional myosins and, as a result, have identified 16 potential unconventional myosin genes. These genes include 7 myosins-I, 2 myosins-V, 1 myosin-VI, 3 myosins-VII, 2 myosins-IX, and 1 myosin-X. The map location of 5 of these genes was identified in human chromosomes by fluorescence in situ hybridization. (C) 1996 Academic Press, Inc.