Grip strength and the risk of incident Alzheimer's disease
Grip strength and the risk of incident Alzheimer's disease
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DOI：
10.1159/000109498
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发表时间：
2007-01-01
影响因子：
5.7
通讯作者：
Bennett, David A.
中科院分区：
文献类型：
--
作者：
Buchman, Aron S.;Wilson, Robert S.;Bennett, David A.
力量下降在老年人中很常见，但关于其与阿尔茨海默病 (AD) 之间关系的数据很少。我们研究了 877 名基线时没有痴呆的老年人的力量水平和变化率与 AD 风险之间的关系。在根据年龄、性别和教育程度进行调整的比例风险模型中，基线握力每下降 1-Ib，AD 风险就会增加约 1.5%（HR，0.986；95% CI，0.973 - 0.998）。即使排除了在随访的前 5 年中患 AD 的人，这些结果仍然存在。在随后的模型中，研究了握力年变化率与 AD 事件之间的关系，握力每年每下降 1-Ib，AD 风险就会增加约 9%（HR，0.915；95% CI，0.884 - 0.948）。在控制体重指数、帕金森病体征、身体和认知活动、抑郁症状、血管疾病和危险因素、社交网络和早期社会经济状况的水平和变化率后，结果相似。老年体力下降与 AD 风险增加相关。版权所有 (c) 2007 S. Karger AG，巴塞尔。
Decline in strength is common in older persons but little data are available about its association with Alzheimer's disease (AD). We studied the association of level of and rate of change in strength in 877 older persons without dementia at baseline and risk of AD. In a proportional hazards model adjusted for age, sex and education, each 1-Ib decrease in grip strength at baseline was associated with about a 1.5% increase in the risk of AD ( HR, 0.986; 95% CI, 0.973 - 0.998). These results persisted even after excluding persons who developed AD in the first 5 years of follow- up. In a subsequent model examining the association of the annual rate of change in grip strength with incident AD, each 1-Ib annual decline in grip strength was associated with about a 9% increase in the risk of AD (HR, 0.915; 95% CI, 0.884 - 0.948). Results were similar after controlling for level and rate of change in body mass index, parkinsonian signs, physical and cognitive activity, depressive symptoms, vascular diseases and risk factors, social networks and early-life socioeconomic status. Declining strength in old age is associated with an increased risk of AD. Copyright (c) 2007 S. Karger AG, Basel.