The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target.
The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target.
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ASIC1a 在癫痫中的作用：潜在的治疗靶点。
DOI：
10.2174/1570159x19666210402102232
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发表时间：
2021
影响因子：
5.3
通讯作者：
Meng, Hongmei
中科院分区：
文献类型：
--
作者：
Cheng, Yu;Zhang, Wuqiong;Li, Yue;Jiang, Ting;Mamat, Buhajar;Zhang, Yunhai;Wang, Famin;Meng, Hongmei
癫痫是人类最常见的脑部疾病之一。组织酸中毒是致痫灶的常见现象。此外，其在癫痫发生中的作用仍不清楚。酸感应离子通道-1a （ASIC1a）代表了一种评估新疗法的潜在方法。ASIC1a是一种蛋白门控的阳离子通道，主要表达于哺乳动物大脑。它已被证明在多种疾病的病理机制中发挥重要作用，包括中风、癫痫和多发性硬化症。数据来源于Web of Science， Medline, PubMed，检索关键词：“酸感离子通道1a”或“ASIC1a”和“癫痫”或“癫痫发作”。ASIC1a在癫痫中的作用仍有争议；它可能是一个有希望的治疗癫痫的靶点。本文就ASIC1a的结构、转运及分子机制进行综述，以期进一步阐明ASIC1a在癫痫中的作用。
Epilepsy represents one of the most common brain diseases among humans. Tissue acidosis is a common phenomenon in epileptogenic foci. Moreover, its role in epileptogenesis remains unclear. Acid-sensing ion channel-1a (ASIC1a) represents a potential way to assess new therapies. ASIC1a, mainly expressed in the mammalian brain, is a type of protein-gated cation channel. It has been shown to play an important role in the pathological mechanism of various diseases, including stroke, epilepsy, and multiple sclerosis. Data were collected from Web of Science, Medline, PubMed, through searching for these keywords: “Acid-sensing ion channels 1a” or “ASIC1a” and “epilepsy” or “seizure”. The role of ASIC1a in epilepsy remains controversial; it may represent a promising therapeutic target of epilepsy. This review is intended to provide an overview of the structure, trafficking, and molecular mechanisms of ASIC1a in order to elucidate the role of ASIC1a in epilepsy further.