BONE MORPHOGENETIC PROTEIN EXPRESSION IN HUMAN ATHEROSCLEROTIC LESIONS
BONE MORPHOGENETIC PROTEIN EXPRESSION IN HUMAN ATHEROSCLEROTIC LESIONS
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DOI：
10.1172/jci116391
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发表时间：
1993-04-01
影响因子：
15.9
通讯作者：
DEMER, LL
中科院分区：
文献类型：
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作者：
BOSTROM, K;WATSON, KE;DEMER, LL
与动脉粥样硬化相关的动脉壁钙化通常包含完全形成的骨组织，包括骨髓。细胞起源尚不清楚。在这项研究中，骨形态发生蛋白-2a，成骨细胞分化的一个有力的因素，被发现在钙化的人类动脉粥样硬化斑块中表达。此外，从主动脉壁培养的细胞形成类似于骨细胞培养物中发现的钙化结节，并在长期培养中表达骨形态发生蛋白-2a。这些结节中的主要细胞具有微血管周细胞的免疫细胞化学特征，能够分化成骨细胞。免疫组化法在牛和人主动脉内膜中也发现了周细胞样细胞。这些发现表明，动脉钙化是一个类似于骨形成的调节过程，可能由周细胞样细胞介导。
Artery wall calcification associated with atherosclerosis frequently contains fully formed bone tissue including marrow. The cellular origin is not known. In this study, bone morphogenetic protein-2a, a potent factor for osteoblastic differentiation, was found to be expressed in calcified human atherosclerotic plaque. In addition, cells cultured from the aortic wall formed calcified nodules similar to those found in bone cell cultures and expressed bone morphogenetic protein-2a with prolonged culture. The predominant cells in these nodules had immunocytochemical features characteristic of microvascular pericytes that are capable of osteoblastic differentiation. Pericyte-like cells were also found by immunohistochemistry in the intima of bovine and human aorta. These findings suggest that arterial calcification is a regulated process similar to bone formation, possibly mediated by pericyte-like cells.