A Phase-Change Mediated Intelligent Nanoplatform for Chemo/Photothermal/Photodynamic Therapy of Cancer
A Phase-Change Mediated Intelligent Nanoplatform for Chemo/Photothermal/Photodynamic Therapy of Cancer
复制标题
用于癌症化疗/光热/光动力治疗的相变介导的智能纳米平台
DOI：
10.1002/adhm.202202245
复制
发表时间：
2022-12-11
影响因子：
10
通讯作者：
Dong, Chunyan
中科院分区：
文献类型：
--
作者：
Hu, Xiaochun;Li, Hui;Dong, Chunyan
到目前为止，化疗仍然是癌症治疗的主要策略。然而，化疗耐药和全身副作用的出现往往严重影响治疗和预后。本文构建了一种基于树枝状介孔有机硅纳米粒子（DMON）的智能纳米平台。包封的相变材料1-十四醇（TD）可以充当“看门人”，并且能够基于温度变化响应性地释放药物。同时，聚乙二醇（PEG）被用来改善可渗透性和生物相容性。选择顺铂作为化疗药物的模型药物，将顺铂与吲哚菁绿色（ICG）共载于DMON中，制备DMON-PEG-顺铂/ICG-TD（DPCIT）。激发，由ICG在NIR-激光照射下诱导的高热和活性氧将引发TD的相变以释放顺铂，从而导致联合治疗（化学/光热/光动力治疗）。结果表明，激光照射下，DPCIT能有效地杀伤癌细胞，抑制肿瘤生长。此外，所设计的纳米平台在体内显示出最小的全身毒性，相反，通过顺铂的直接治疗可以观察到明显的肝损伤。总之，本研究可能为化疗药物的靶向递送和控制释放提供一种通用方法，以实现协同增强的多模式肿瘤治疗。
Up to now, chemotherapy is still the main strategy for cancer treatment. However, the emergence of chemo-resistance and systemic side effects often seriously affects the treatment and prognosis. Herein, an intelligent nanoplatform based on dendritic mesoporous organosilica nanoparticles (DMON) is constructed. The encapsulated phase-change material, 1-tetradecanol (TD) can serve as a "doorkeeper" and enable the responsive release of drugs based on the temperature changes. Meanwhile, polyethylene glycol (PEG) is used to improve the dispersibility and biocompatibility. Cisplatin is chosen as the model of chemotherapy drug, which is co-loaded with indocyanine green (ICG) in DMON to produce DMON-PEG-cisplatin/ICG-TD (DPCIT). Exciting, the hyperthermia and reactive oxygen species induced by ICG under the NIR-laser irradiation will initiate a phase transition of TD to release cisplatin, thus leading a combined therapy (chemo/photothermal/photodynamic therapy). The results indicated that under laser irradiation, DPCIT can kill cancer cells and inhibit tumor growth efficiently. In addition, the designed nanoplatform reveals minimal systemic toxicity in vivo, in contrast, the distinct liver damage can be observed by the direct treatment of cisplatin. Overall, this research may provide a general approach for the targeted delivery and controlled release of chemotherapy drugs to realize a cooperatively enhanced multimodal tumor therapy.