Predicting Response of Spontaneously Firing Afferents to Prosthetic Pulsatile Stimulation.
Predicting Response of Spontaneously Firing Afferents to Prosthetic Pulsatile Stimulation.
复制标题
预测自发放电传入神经对假肢脉动刺激的反应。
DOI：
10.1109/embc44109.2020.9175282
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Fridman,GeneY
中科院分区：
文献类型：
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作者：
Steinhardt,CynthiaR;Fridman,GeneY
脉冲电刺激用于神经假体，如前庭假体。在一个健康的前庭系统中，头部运动是由传入神经元自发基线频率附近的放电频率的变化来编码的。对于患有双侧前庭功能障碍(BVD)的人来说，头部运动不再调节放电频率。前庭假体使用陀螺仪来检测头部运动，并以一种模仿自然调节的方式直接刺激神经元。前庭功能的适当恢复依赖于刺激的能力，以唤起与健康系统相同的放电模式。因此，有必要了解不同刺激参数下产生的放电频率。脉搏神经调节中经常控制的两个刺激参数是脉率和脉冲幅度。前庭神经的神经记录实验与关于脉搏频率和诱发的棘波活动之间的关系的普遍假设相矛盾，而脉搏幅度和神经活动之间的关系还没有被探索过。在这里，我们使用一个完善的前庭传入的计算模型来模拟对不同脉搏频率和幅度的反应。我们证实我们的模拟神经结果与现有的实验数据是一致的。最后，我们建立了“动作电位碰撞”(APC)方程，该方程将诱发放电定义为自发放电频率、脉冲频率和脉冲幅度的函数。我们表明，通过考虑脉冲和自发放电之间的相互作用，这种关系可以成功地预测模拟的前庭活动。
Pulsatile electrical stimulation is used in neural prostheses such as the vestibular prosthesis. In a healthy vestibular system, head motion is encoded by changes in the firing rates of afferents around their spontaneous baseline rate. For people suffering from bilateral vestibular disorder (BVD), head motion no longer modulates firing rate. Vestibular prostheses use a gyroscope to detect head motion and stimulate neurons directly in a way that mimics natural modulation. Proper restoration of vestibular function relies on the ability of stimulation to evoke the same firing patterns as the healthy system. For this reason, it is necessary to understand what firing rates are produced for different stimulation parameters. Two stimulation parameters commonly controlled in pulsatile neuromodulation are pulse rate and pulse amplitude. Previous neural recording experiments in the vestibular nerve contradict widely held assumptions about the relationship between pulse rates and evoked spike activity, and the relationship between pulse amplitude and neural activity has not been explored. Here we use a well-established computational model of the vestibular afferent to simulate responses to different pulse rates and amplitudes. We confirm that our simulated neural results agree with the existing experimental data. Finally, we developed the "Action Potential Collision" (APC) equation that defines induced firing as a function of spontaneous firing rate, pulse rate, and pulse amplitude. We show that this relationship can successfully predict simulated vestibular activity by accounting for interactions between pulses and spontaneous firing.