Health-related quality of life over chemotherapy course among individuals with early-stage breast cancer: the association of social determinants of health and neighborhood socioeconomic disadvantage.
Health-related quality of life over chemotherapy course among individuals with early-stage breast cancer: the association of social determinants of health and neighborhood socioeconomic disadvantage.
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早期乳腺癌患者化疗期间的健康相关生活质量：健康的社会决定因素与社区社会经济劣势的关联。
DOI：
10.1007/s00520-024-08429-y
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Rosenzweig,MargaretQuinn
中科院分区：
文献类型：
--
作者：
You,Kai-Lin;Sereika,SusanM;Bender,CatherineM;Hamilton,JillB;Mazanec,SusanR;Brufsky,Adam;Rosenzweig,MargaretQuinn
PurposeThis study aims to examine relationships between health-related quality of life（HRQOL），social determinants of health，and neighborhood socioeconomic disadvantage in individuals with early-stage breast cancer（ESBC）during chemotherapy.MethodsThis is a longitudinal study that recruited Black and白色women with ESBC receiving chemotherapy.参与者在每个化疗周期前完成问卷调查，记录他们在基线时的社会人口统计学信息和癌症治疗功能评估-一般（FACT-G），以报告他们的HRQOL。采用线性混合模型研究FACT-G评分，自我报告的种族，和面积剥夺指数（ADI）之前和最后一个化疗周期，化疗治疗的持续时间作为协变量之间的关联。ResultsA共84个黑色和146个白色妇女ESBC完成了调查。线性混合模型结果表明，在整个化疗过程中，报告为黑人的ESBC女性的身体健康状况明显比报告为白色的女性差，平均低0.22分（p= 0.02）。患有ESBC的黑人和白色女性在化疗期间都经历了功能健康下降，黑人女性一直报告得分低于白色女性，种族组之间功能健康随时间的变化不同（p= 0.03）。参与者的ADI国家排名没有显着相关的HRQOL在整个chemotherapy.ConclusionsThese研究结果强调可能的种族差异，在某些方面的HRQOL在化疗期间ESBC的妇女。今后的研究应考虑进一步评估可能造成这些差异的生活压力和过去的歧视和种族主义经历，并指导积极的干预措施。
PurposeThis study aimed to examine relationships between health-related quality of life (HRQOL), social determinants of health, and neighborhood socioeconomic disadvantage in individuals with early-stage breast cancer (ESBC) during chemotherapy.MethodsThis is a longitudinal study that recruited Black and White women with ESBC receiving chemotherapy. Participants completed questionnaires recording their sociodemographic information at baseline and the Functional Assessment of Cancer Therapy–General (FACT-G) to report their HRQOL before each chemotherapy cycle. Linear mixed modeling was employed to examine the associations between FACT-G scores, self-reported race, and area deprivation index (ADI) before and at the last chemotherapy cycle, with the duration of chemotherapy treatment as a covariate.ResultsA total of 84 Black and 146 White women with ESBC completed the surveys. Linear mixed modeling results suggested that women with ESBC who reported being Black experienced significantly worse physical well-being than those who reported being White throughout chemotherapy, with a 0.22-point lower average (p= 0.02). Both Black and White women with ESBC experienced decreased functional well-being over the chemotherapy, and Black women consistently reported lower scores than White women, with the change in functional well-being over time differing between racial groups (p= 0.03). Participants’ ADI national percentiles were not significantly associated with their HRQOL throughout chemotherapy.ConclusionsThese findings underscore possible racial differences in some dimensions of HRQOL during chemotherapy among women with ESBC. Future research should consider further assessing life stressors and past experiences of discrimination and racism that may contribute to these disparities and guide proactive interventions.