MUSCARINIC AGONISTS PROVIDE A NEW CLASS OF ACARICIDE
MUSCARINIC AGONISTS PROVIDE A NEW CLASS OF ACARICIDE
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DOI：
10.1038/262220a0
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发表时间：
1976-01-01
期刊：
影响因子：
64.8
通讯作者：
PURVIS, SR
中科院分区：
文献类型：
--
作者：
BIGG, DCH;PURVIS, SR
蜱对化学控制方法的抗性是一个日益严重的问题1 -5，迫切需要具有高杀螨活性和低哺乳动物毒性的新类别化合物。在寻找新型杀螨剂时，神经系统是主要目标，尽管有证据表明γ-氨基丁酸和谷氨酸在节肢动物神经传递中的作用，但乙酰胆碱是唯一确定的神经递质6 -9。到目前为止，只有乙酰胆碱酯酶在胆碱能神经传递的中断中发挥了重要作用。抗胆碱能药物，如阿托品，是无效的，而除了尼古丁以外的胆碱模拟物几乎没有研究。我们现在报道某些毒蕈碱激动剂是有效的杀螨剂。
THE resistance of ticks to chemical methods of control is an increasingly serious problem1–5, and new classes of compounds with high acaricidal activity and low mammalian toxicity are needed urgently. In the search for novel acaricides the nervous system is a prime target, and, in spite of evidence about the role ofγ-aminobutyrate and gluta-mate in arthropod nervous transmission, acetylcholine is the only well established neurotransmitter6–9. So far only acetylcholinesterases have achieved an important role in the disruption of cholinergic neurotransmission. Anti-cholinergics, such as atropine, are ineffective, and cholino-mimetics other than nicotine have been little investigated. We now report that certain muscarinic agonists are potent acaricides.