[Examination of the escape phenomenon in disease modifying antirheumatic drugs].
[Examination of the escape phenomenon in disease modifying antirheumatic drugs].
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[疾病缓解抗风湿药物中逃逸现象的检查]。
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Y. Gomita
中科院分区：
文献类型：
--
作者：
Yoichi Kawasaki;M. Moriyama;K. Shibata;Y. Gomita
尽管缓解病情抗风湿药物（DMARD）用于治疗类风湿性关节炎（RA），但在复发（逃逸现象）的情况下药物的选择缺乏明确的标准。因此，我们调查了逃亡率和条件以及逃亡发生后使用的制剂。对松原五月花医院的门诊患者进行了研究，该患者在 2003 年 5 月之前的 4 年内有 DMARD 给药史。接受柳氮磺吡啶（SASP）治疗的患者逃逸率较高，而接受甲氨蝶呤（MTX）和布西拉明（BC）治疗的患者逃逸率较低。 MTX和BC的持续给药时间较长，而金硫苹果酸钠(GST)的持续给药时间较短。 BC 和 Actarit (AR) 逐渐升高 C 反应蛋白 (CRP) 水平和红细胞沉降率 (ESR)。在接受SASP和MTX的患者中，在逃逸发生前2个月出现高水平CRP和高ESR，并且在逃逸后保持不变。逃亡后使用的药物以SASP和BC替换为其他DMARD。接受 MTX 治疗的患者通常会与其他 DMARD 联合用药。综上所述，目前的结果阐明了 DMARD 逃逸的特征，并将有助于 RA 的适当药物治疗。
Although disease-modifying antirheumatic drugs (DMARDs) are used in the treatment of rheumatoid arthritis (RA), the selection of agents in the case of relapse (escape phenomenon) lacks clear-cut standards. Therefore we investigated the rate and conditions of escape as well as the agents used after escapes had occurred. Outpatients of the Matsubara Mayflower Hospital with a history of DMARD administration during the 4 years prior to May 2003 were studied. Those receiving salazosulfapyridine (SASP) had a high escape rate and those receiving methotrexate (MTX) and bucillamine (BC) had a low rate. The continuous duration of administration was long for MTX and BC, but short for sodium aurothiomalate (GST). BC and Actarit (AR) gradually elevated C-reactive protein (CRP) levels and the erythrocyte sedimentation rate (ESR). In patients receiving SASP and MTX, a high level of CRP and high ESR was seen 2 months prior to the occurrence of escape and remained unchanged after escape. With respect to the agents used after escape, SASP and BC were substituted with other DMARDs. A combination with other DMARDs was usually administered to patients who had been receiving MTX. Taken together, the present results clarified the characteristics of DMARD escape and will contribute to the appropriate pharmacotherapy for RA.
类风湿性关节炎在疾病的前 2 年内有显着的放射学损伤的证据。
DOI：
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发表时间：
1989
期刊：
The Journal of rheumatology
影响因子：
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作者：
Fuchs,HA;Kaye,JJ;Callahan,LF;Nance,EP;Pincus,T
通讯作者：
Pincus,T