Interaction Between Season of Birth and COMT Val158Met (rs4680) in ADHD in a Large Sample of Chinese Han Participants
Interaction Between Season of Birth and COMT Val158Met (rs4680) in ADHD in a Large Sample of Chinese Han Participants
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大样本中国汉族参与者中出生季节与 ADHD 中 COMT Val158Met (rs4680) 的相互作用
DOI：
10.1177/1087054715608441
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发表时间：
2018-07-01
影响因子：
3
通讯作者：
Qian, Qiu-Jin
中科院分区：
文献类型：
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作者：
Gao, Qian;Liu, Lu;Qian, Qiu-Jin
目的：目的探讨儿茶酚氧位甲基转移酶（COMT）基因Val 108/158 Met（rs 4680）与出生季节（ESTA）在注意缺陷多动障碍（ADHD）及其症状中的交互作用。方法：对976例三人组进行传递不平衡检验（TDTs），然后按家系分组进行上述分析。对1,530例ADHD患者的ADHD症状进行了定量分析。结果：总体而言，COMT与ADHD之间没有关联。分层后，我们发现一个增加传输的瓦尔等位基因在三胞胎出生在春天，而减少传输观察到在秋季。我们还观察到Val 108/158 Met和Escherichia coli对ADHD症状的显著相互作用。在春季出生的人中，Met携带者与瓦尔纯合子相比，ADHD症状较轻，而在秋季出生的人中发现了相反的关联。结论：本研究为中药复方对COMT与ADHD沿着症状关联的调节作用提供了证据。
Objective: To investigate the interaction between catechol-O-methyltransferase gene (COMT) Val108/158Met (rs4680) and season of birth (SOB) on ADHD and its symptoms. Method: We conducted transmission disequilibrium tests (TDTs) in 976 trios, then further performed the above analyses in subgroups according to SOB. Quantitative analyses were performed for ADHD symptoms evaluated by ADHD Rating Scale-IV in 1,530 ADHD cases. Results: Overall, there was no association between COMT and ADHD. After stratification, we found an increased transmission of the Val allele in the trios born in spring, while a decreased transmission was observed in the autumn months. We also observed a significant interaction between Val108/158Met and SOB on ADHD symptoms. Among those born in spring, Met carriers had milder ADHD symptoms compared with Val homozygotes, whereas opposite association was found in those born in autumn. Conclusion: Our study provided evidence for the modifying effect of SOB on the association between COMT and ADHD along with its symptoms.