Rechargeable Antibacterial and Antifungal Polymeric Silver Sulfadiazines
Rechargeable Antibacterial and Antifungal Polymeric Silver Sulfadiazines
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DOI：
10.1177/0883911509340198
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发表时间：
2009-07-01
影响因子：
1.7
通讯作者：
Fong, Hao
中科院分区：
文献类型：
--
作者：
Cao, Zhengbing;Sun, Xinbo;Fong, Hao
将丙烯酰磺胺嘧啶与甲基丙烯酸甲酯共聚，然后用稀硝酸银水溶液处理，制得了聚甲基丙烯酸甲酯(PMMA)基可充电抗菌抗真菌聚合物磺胺嘧啶银盐。用红外光谱、核磁共振氢谱、X射线光电子能谱和热重分析对样品的化学结构进行了表征。在接触时，以PMMA为基础的聚合物磺胺嘧啶银对10(8)-10(9)cfu/mL革兰氏阴性杆菌、金黄色葡萄球菌(革兰氏阳性菌)和热带念珠菌(酵母菌)在10分钟内达到100%灭活。Kirby-Bauer测试数据表明，抗菌和抗真菌作用是通过接触杀灭实现的，没有银离子从新共聚物中渗出。在正常储存条件下，抗菌和抗真菌功能至少稳定12个月。硝酸银处理可以恢复失去的任何抗菌和抗真菌活性；这种重新充电可以根据需要重复进行，以实现长期保护。这些特性使新型基于PMMA的聚合物磺胺嘧啶银具有吸引力，可广泛应用于医疗(整形外科)、牙科和其他相关应用，以降低高接触/高风险表面和异物相关感染的细菌和真菌污染风险。
Poly(methyl methacrylate) (PMMA)-based rechargeable antibacterial and antifungal polymeric silver sulfadiazines were prepared by copolymerizing acryloyl sulfadiazine with methyl methacrylate and sequentially treating the copolymers with dilute silver nitrate aqueous solutions. The chemical structures of the samples were characterized by FT-IR, H-1-NMR, XPS, and TGA analyses. On contact, the PMMA-based polymeric silver sulfadiazines provided 100% inactivation of 10(8)-10(9) CFU/mL of Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria) in 10 min, and Candida tropicalis (yeast) in 30 min. Kirby-Bauer test data indicated that the antibacterial and antifungal effects were achieved through contact kill; no silver ions leached out of the new copolymers. The antibacterial and antifungal functions were stable for at least 12 months under normal storage conditions. Silver nitrate treatments regenerated any lost of antibacterial and antifungal activity; this recharging can be repeated as needed to achieve long-term protection. These properties make the new PMMA-based polymeric silver sulfadiazines attractive candidates for a broad range of medical (orthopedic), dental, and other related applications to reduce the risks of bacterial and fungal contamination on high-touch/high-risk surfaces and foreign body-related infections.