A Review on Toxicity of 2‐Bromopropane: Mainly on its Reproductive Toxicity
A Review on Toxicity of 2‐Bromopropane: Mainly on its Reproductive Toxicity
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2-溴丙烷毒性研究进展：主要是其生殖毒性
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
M. Kamijima
中科院分区：
文献类型：
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作者：
Y. Takeuchi;G. Ichihara;M. Kamijima
2‐溴丙烷的毒性研究进展：主要是其生殖毒性[j]。2‐溴丙烷在封闭系统中主要用作药品、农药和其他化学品的中间体。最近，它已被用作开放式系统的替代溶剂，而不是消耗臭氧层的氯氟烃。1995年，在韩国一家工厂，接触含2 -溴丙烷溶剂的工人爆发了生殖和造血疾病。此后，一些动物实验显示，2‐溴丙烷对雌性和雄性生殖器官和造血器官有严重的毒性作用。我们根据流行病学调查和动物实验的最新数据对2‐溴丙烷的毒性进行了综述。将结构相关的溴丙烷的毒性与2‐溴丙烷的毒性进行了比较，并讨论了其风险评估。研究结论如下：1。2‐溴丙烷在人类和实验动物的两性中都具有特定的生殖和造血毒性。2. 它可能损害睾丸，尤其是男性的精原细胞。3. 它会损害卵巢功能，导致雌性发情周期紊乱和卵母细胞丢失。4. 它会损害骨髓，导致全血细胞减少症。5. 它在细菌突变试验中具有弱的强致突变性。6. 一项风险评估表明，建议将约0.3 - 10ppm作为2 -溴丙烷的职业暴露限值。
A Review on Toxicity of 2‐Bromopropane : Mainly on its Reproductive Toxicity: Yasuhiro Takeuchi, et al. Department of Hygiene, Nagoya University School of Medicine—2‐Bromopropane has been used mostly as an intermediate for medicines, pesticides and other chemicals in closed systems. Recently it has come to be used as an alternative solvent in open systems instead of ozone layer depleting chlorofluorocarbons. An outbreak of reproductive and hematopoietic disorders occurred in workers exposed to solvents containing 2‐bromopropane in a Korean factory in 1995. After that some animal experiments revealed that 2‐bromopropane has a severe toxic effect on the female and male reproductive organs and hematopoietic organs. We reviewed the toxicity of 2‐bromopropane based on the recent data obtained in epidemiological surveys and animal experiments. Toxicities of structurally related bromopropanes were compared with that of 2‐bromopropane and its risk assessment was discussed. The conclusions are as follows: 1. 2‐Bromopropane has a specific reproductive and hematopoietic toxicity in both sexes in humans and experimental animals. 2. It could impair the testes, especially spermatogonia in males. 3. It could impair the ovarian function, resulting in a disturbed estrous cycle and loss of oocytes in females. 4. It could impair the bone marrow, resulting in pancytopenia. 5. It has a weak potent mutagenicity in bacterial mutation assays. 6. A risk assessment suggests that around 0.3‐10 ppm might be recommended as an occupational exposure limit for 2‐bromopropane.
卤代丙烷和丙烯的诱变活性：溴和氯定位的影响。
影响因子：
5.1
作者：
Låg,M;Omichinski,JG;Dybing,E;Nelson,SD;Søderlund,EJ
通讯作者：
Søderlund,EJ
溴和氯定位对卤化丙烷诱导肾和睾丸毒性的影响。
影响因子：
4.1
作者：
Låg,M;Søderlund,EJ;Omichinski,JG;Brunborg,G;Holme,JA;Dahl,JE;Nelson,SD;Dybing,E
通讯作者：
Dybing,E