End-systolic pressure-volume, pressure-length, and stress-strain relations in canine hearts.
End-systolic pressure-volume, pressure-length, and stress-strain relations in canine hearts.
复制标题
犬心脏的收缩末期压力-容积、压力-长度和应力-应变关系。
DOI：
10.1152/ajpheart.1985.249.3.h648
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
M. Nakamura
中科院分区：
文献类型：
--
作者：
S. Kaseda;H. Tomoike;I. Ogata;M. Nakamura
本文测定了犬在体心脏收缩末期压力-容积关系（ESPVR），并与收缩末期压力-长度（ESPLR）或应力-应变关系（ESSSR）进行了比较。圆周段长度和壁厚在赤道和外部的长和短轴直径的左心室（LV）的sonomicrometrically确定，和LV体积计算的椭圆体模型。赤道处的周向壁应力采用极薄壳模型计算。收缩状态增强了静脉注射多巴酚丁胺和抑制心得安。在通过暂时阻塞下腔静脉（IVC）降低动脉压的过程中测定ESPVR、ESPLR和ESSSR。收缩末期压从108 +/- 3至71 +/- 2 mmHg变化期间，ESPVR、ESPLR和ESSSR呈线性，与变力性状态无关（r> 0.92）。这些关系的斜率增加类似的情况下，多巴酚丁胺和普萘洛尔后减少，但外推的X轴截距的ESPVR，ESPLR和ESSSR保持不变。因此，ESPVR的斜率是变力性状态所特有的，当无节段性室壁运动异常时，ESPLR和ESSSR均可作为ESPVR的替代物。
End-systolic pressure-volume relationship (ESPVR) of the in situ heart in the dog was measured during changes in contractile state and was compared with end-systolic pressure-length (ESPLR) or stress-strain relationship (ESSSR). Circumferential segmental length and wall thickness at the equator and external long and short axis diameters of the left ventricle (LV) were determined sonomicrometrically, and LV volume was calculated by an ellipsoidal model. Circumferential wall stress at the equator was calculated by a very thin shell model. Contractile state was enhanced by an intravenous infusion of dobutamine and was suppressed by propranolol. ESPVR, ESPLR, and ESSSR were determined during a reduction of arterial pressure by occluding temporarily the inferior caval vein (IVC). ESPVR, ESPLR, and ESSSR during changes in end-systolic pressure from 108 +/- 3 to 71 +/- 2 mmHg were linear, irrespective of inotropic states (r greater than 0.92). Slopes of these relationships increased similarly in case of dobutamine and were reduced after propranolol, yet the extrapolated X-axis intercept of ESPVR, ESPLR, and ESSSR remained unchanged. Thus the slope of ESPVR is unique to the inotropic state, and both ESPLR and ESSSR are useful as a substitute for ESPVR when there is no regional wall motion abnormality.