Developments in the scientific understanding of osteoarthritis.
Developments in the scientific understanding of osteoarthritis.
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DOI：
10.1186/ar2655
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发表时间：
2009
影响因子：
4.9
通讯作者：
Attur M
中科院分区：
文献类型：
--
作者：
Abramson SB;Attur M
骨关节炎通常是一种进行性和致残性疾病，它发生在各种危险因素的背景下--如高龄、肥胖和创伤--这些因素共同在关节组织内引发一连串的病理生理事件。骨关节炎的一个重要的新兴主题是将焦点从软骨疾病扩大到“整个关节”的疾病。滑膜、骨和软骨都参与了导致进行性关节退变的病理过程。在过去十年中出现的其他主题包括软骨降解和修复的新机制，生物力学和生化途径之间的关系，炎症的重要性，以及遗传学所起的作用。在这篇综述中，我们总结了目前对骨关节炎的科学认识，并检查了导致进展性疾病的病理生物学机制。
Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a variety of risk factors – such as advancing age, obesity, and trauma – that conspire to incite a cascade of pathophysiologic events within joint tissues. An important emerging theme in osteoarthritis is a broadening of focus from a disease of cartilage to one of the 'whole joint'. The synovium, bone, and cartilage are each involved in pathologic processes that lead to progressive joint degeneration. Additional themes that have emerged over the past decade are novel mechanisms of cartilage degradation and repair, the relationship between biomechanics and biochemical pathways, the importance of inflammation, and the role played by genetics. In this review we summarize current scientific understanding of osteoarthritis and examine the pathobiologic mechanisms that contribute to progressive disease.
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DOI：
10.1084/jem.182.6.2097
发表时间：
1995-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Amin AR;Di Cesare PE;Vyas P;Attur M;Tzeng E;Billiar TR;Stuchin SA;Abramson SB
通讯作者：
Abramson SB
影响因子：
7
作者：
Bakker, AC;van de Loo, FAJ;van den Berg, WB
通讯作者：
van den Berg, WB
影响因子：
--
作者：
Blair-Levy, J. M.;Watts, C. E.;Lipsky, P. E.
通讯作者：
Lipsky, P. E.
影响因子：
--
作者：
Clements, KM;Price, JS;Mason, RM
通讯作者：
Mason, RM
影响因子：
--
作者：
Garnero, P;Peterfy, C;Schoenharting, M
通讯作者：
Schoenharting, M