Comparison of the effects of Artemisia vulgaris and Artemisia absinthium growing in western Anatolia against trichinellosis (Trichinella spiralis) in rats
Comparison of the effects of Artemisia vulgaris and Artemisia absinthium growing in western Anatolia against trichinellosis (Trichinella spiralis) in rats
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DOI：
10.1016/j.exppara.2008.01.012
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发表时间：
2008-05-01
影响因子：
2.1
通讯作者：
Guruz, Yuksel
中科院分区：
文献类型：
--
作者：
Caner, Ayse;Doskaya, Mert;Guruz, Yuksel
旋毛虫病通常引起人类腹泻，更罕见地引起发烧、眶周水肿和肌炎，通常用苯并咪唑衍生物治疗。已发现蒿属植物可有效对抗多种寄生虫。在本研究中，首次在大鼠中检测了艾蒿和苦艾对旋毛虫病（旋毛虫病）的功效。疾病肠内（成虫）阶段的旋毛镜检查和人工消化结果表明，300mg/kg剂量的苦艾草和苦艾草地上部分的甲醇提取物使舌幼虫率降低75.6%和63.5%，膈肌幼虫率降低53.4%和37.7%，股四头肌幼虫率降低67.8%和46.2%，大鼠二头肌和三头肌分别为 66.7% 和 60.5%。此外，在肠胃外（包囊幼虫）阶段，600 mg/kg 剂量的寻常曲霉和苦艾曲霉提取物使舌头幼虫率降低了 66.4% 和 59.9%，膈肌幼虫率降低了 57.4% 和 50.0%，股四头肌幼虫率降低了 47.6% 和 43.7%，腹腔幼虫率降低了 60.2% 和 46.4%。分别是大鼠的二头肌-三头肌。抗体分析还表明，A. vulgaris 显着降低了肠内和肠外阶段的抗体反应（P < 0.05）。因此，本研究的结果表明，普通曲霉可能是对抗旋毛虫病的替代药物。 (C) 2008 Elsevier Inc. 保留所有权利。
Trichinellosis often causing diarrhea and more rarely fever, periorbital edema and myositis in human, is commonly treated with benzimidazole derivatives. The Artemisia genus has been found to be effective against a variety of parasites. In the present study, the efficacy against trichinellosis (Trichinella spiralis) of Artemisia vulgaris and Artemisia absinthium was examined for the first time in rats. The results of trichinoscopy and artificial digestion, during the enteral (adult) phase of the illness show that 300 mg/kg doses of methanol extracts of the aerial parts of A. vulgaris and A. absinthium reduced the larval rate by 75.6% and 63.5% in tongue, 53.4% and 37.7% in diaphragm, 67.8% and 46.2% in quadriceps, and 66.7% and 60.5% in biceps-triceps muscles of rats, respectively. Furthermore, during the parenteral (encapsulated larvae) phase, 600 mg/kg doses of A. vulgaris and A. absinthium extracts decreased the larval rate by 66.4% and 59.9% in tongue, 57.4% and 50.0% in diaphragm, 47.6% and 43.7% in quadriceps, 60.2% and 46.4% in biceps-triceps muscles of rats, respectively. Analysis of antibody also showed that A. vulgaris significantly reduced the antibody response (P < 0.05) during the enteral and parenteral phases. Thus, the results of the present study revealed that A. vulgaris could be an alternative drug against trichinellosis. (C) 2008 Elsevier Inc. All rights reserved.