Selective involvement of superior frontal cortex during working memory for shapes.
Selective involvement of superior frontal cortex during working memory for shapes.
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DOI：
10.1152/jn.91299.2008
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发表时间：
2010
影响因子：
2.5
通讯作者：
L. Yee;Katherine Roe;S. Courtney
中科院分区：
文献类型：
--
作者：
L. Yee;Katherine Roe;S. Courtney
背侧视觉通路和腹侧视觉通路之间的空间/非空间功能分离已经得到了很好的建立，并形成了前额叶皮层（PFC）特定领域理论的基础。然而，在有关前额叶组织的文献中，研究人员提出了一个问题，即在工作记忆过程中观察到的PFC中的解离性质是否等同于在感知的视觉通路中观察到的解离性质。特别是，在工作记忆的位置与对象身份之间的背侧和腹侧PFC的分离已经清楚地存在于一些研究中，但在其他研究中，似乎部分是由于所使用的对象的类型。目前的研究比较了功能性MRI激活延迟识别任务的形状或颜色，两个对象的功能被认为是处理的腹侧通路的知觉识别。形状延迟识别任务的激活大于外侧枕叶皮层的颜色任务，与视觉感知的研究一致。然而，在顶叶和上级额叶皮层中，形状任务比颜色任务的记忆延迟活动更大。上级额叶皮层的活动与形状任务的更好表现有关。相反，在左前额叶中观察到颜色比形状更大的延迟活动，并且这种活动与颜色任务的更好表现相关。这些结果表明，上级额叶皮层有助于完成需要工作记忆来识别物体的任务，但它代表的是与腹侧额叶皮层不同的关于这些物体的信息。
A spatial/nonspatial functional dissociation between the dorsal and ventral visual pathways is well established and has formed the basis of domain-specific theories of prefrontal cortex (PFC). Inconsistencies in the literature regarding prefrontal organization, however, have led to questions regarding whether the nature of the dissociations observed in PFC during working memory are equivalent to those observed in the visual pathways for perception. In particular, the dissociation between dorsal and ventral PFC during working memory for locations versus object identities has been clearly present in some studies but not in others, seemingly in part due to the type of objects used. The current study compared functional MRI activation during delayed-recognition tasks for shape or color, two object features considered to be processed by the ventral pathway for perceptual recognition. Activation for the shape-delayed recognition task was greater than that for the color task in the lateral occipital cortex, in agreement with studies of visual perception. Greater memory-delay activity was also observed, however, in the parietal and superior frontal cortices for the shape than for the color task. Activity in superior frontal cortex was associated with better performance on the shape task. Conversely, greater delay activity for color than for shape was observed in the left anterior insula and this activity was associated with better performance on the color task. These results suggest that superior frontal cortex contributes to performance on tasks requiring working memory for object identities, but it represents different information about those objects than does the ventral frontal cortex.