The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
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DOI：
10.1016/s1074-7613(00)80073-4
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发表时间：
1999-06-01
期刊：
影响因子：
32.4
通讯作者：
Glimcher, LH
中科院分区：
文献类型：
--
作者：
Kim, JI;Ho, IC;Glimcher, LH
IL-4促进初始CD 4（+）T细胞分化为产生IL-4的辅助性T细胞2（Th 2）。以前的工作提供了提示性的，但不是决定性的证据，转录因子c-Maf指导组织特异性表达的IL-4。目前尚不清楚c-Maf是否控制其他Th 2细胞因子基因的转录。为了阐明c-Maf在体内的作用，我们检查了缺乏c-Maf（c-Maf（-/-））的小鼠中细胞因子的产生。c-maf（-/-）小鼠的CD 4（+）T细胞和NK T细胞明显缺乏IL-4的产生。然而，小鼠产生正常水平的IL-13和IgE，并且当在外源性IL-4存在下分化时，c-maf（-/-）T细胞产生近似正常水平的其他Th 2细胞因子。我们认为c-Maf在体内IL-4基因转录中具有关键性和选择性的功能。
IL-4 promotes the differentiation of naive CD4(+) T cells into IL-4-producing T helper 2 (Th2) cells. Previous work provided suggestive but not conclusive evidence that the transcription factor c-Maf directed the tissue-specific expression of IL-4. It was not known whether c-Maf controlled the transcription of other Th2 cytokine genes. To elucidate the role of c-Maf in vivo, we examined cytokine production in mice lacking c-Maf (c-maf(-/-)). CD4(+) T cells and NK T cells from c-maf(-/-) mice were markedly deficient in IL-4 production. However, the mice produced normal levels of IL-13 and IgE, and, when differentiated in the presence of exogenous IL-4, c-maf(-/-) T cells produced approximately normal levels of other Th2 cytokines. We conclude that c-Maf has a critical and selective function in IL-4 gene transcription in vivo.