Brain stem and spinal cord mediation of a serotonergic behavioral syndrome
Brain stem and spinal cord mediation of a serotonergic behavioral syndrome
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脑干和脊髓介导血清素能行为综合征
DOI：
10.1016/0006-8993(75)90500-4
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发表时间：
1975
期刊：
影响因子：
2.9
通讯作者：
H. Klemfuss
中科院分区：
文献类型：
--
作者：
B. Jacobs;H. Klemfuss
使用雄性Sprague-Dawley大鼠检查介导大鼠中观察到的行为综合征的各种组分体征的轴突水平，所述行为综合征由产生增加的突触5-羟色胺或增加的突触后5-羟色胺受体刺激的药物治疗引起。数据表明，该综合征，其特征在于高反应性，多动，静止性震颤，僵硬，相互前爪踩踏，后肢外展，和侧头摆动，是由存在于脑桥，髓质和脊髓的神经机制介导的。注意到在中枢神经系统中的5-羟色胺的作用模型的发展的影响。（PsycInfo数据库记录（c）2022阿帕，保留所有权利）
Used male Sprague-Dawley rats to examine the levels of neuraxis that mediate the various component signs of the behavioral syndrome seen in rats that is caused by pharmacological treatments that produce increased synaptic serotonin or increased stimulation of postsynaptic serotonin receptors. Data indicate that the syndrome, which is characterized by hyperreactivity, hyperactivity, resting tremor, rigidity, reciprocal forepaw treading, hindlimb abduction, and lateral head weaving, is mediated by neural mechanisms present in the pons, medulla, and spinal cord. Implications for the development of a model of the action of serotonin in the CNS are noted.(PsycInfo Database Record (c) 2022 APA, all rights reserved)