Gain of chromosome arm 17q predicts unfavourable outcome in neuroblastoma patients
Gain of chromosome arm 17q predicts unfavourable outcome in neuroblastoma patients
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DOI：
10.1016/s0959-8049(97)00282-7
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发表时间：
1997-09-01
影响因子：
8.4
通讯作者：
Bown, N
中科院分区：
文献类型：
--
作者：
Lastowska, M;Cotterill, S;Bown, N
最近报道了神经母细胞瘤中染色体臂 17q 的增加。我们分析了 45 个肿瘤系列中 17q 状态与其他已知预后特征和临床结果的关系。通过细胞遗传学分析、荧光原位杂交 (FISH) 和比较基因组杂交 (CGH) 检测 17 号染色体状态，并与其他临床和遗传因素相关。通过 Kaplan-Meier 估计计算生存分析。 45 个肿瘤中有 28 个显示出 17q 增益，这与不良预后的既定指标相关； 4 期疾病（P
Gain of chromosome arm 17q has recently been reported in neuroblastoma tumours. We analysed 17q status in relation to other known prognostic features and clinical outcome in a series of 45 tumours. Chromosome 17 status was detected by cytogenetic analysis, fluorescence in situ hybridisation (FISH) and comparative genomic hybridisation (CGH) and correlated with other clinical and genetic factors. Survival analysis was calculated by the Kaplan-Meier estimation. Twenty-eight out of 45 tumours showed 17q gain, and this was associated with established indicators of poor prognosis; stage 4 disease (P