The status of contemporary image-guided modalities in oncologic surgery.
The status of contemporary image-guided modalities in oncologic surgery.
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DOI：
10.1097/sla.0000000000000622
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发表时间：
2015-01
影响因子：
9
通讯作者：
Zinn KR
中科院分区：
文献类型：
--
作者：
Rosenthal EL;Warram JM;Bland KI;Zinn KR
Surgical resection remains the cornerstone of therapy for patients with early stage solid malignancies and more than half of all cancer patients undergo surgery each year. The technical ability of the surgeon to obtain clear surgical margins at the initial resection remains crucial to improve overall survival and long-term morbidity. Current resection techniques are largely based on subjective and subtle changes associated with tissue distortion by invasive cancer. As a result, positive surgical margins occur in a significant portion of tumor resections, which is directly correlated with a poor outcome. A variety of cancer imaging techniques have been adapted or developed for intraoperative surgical guidance that have been shown to improve functional and oncologic outcomes in randomized clinical trials. There are also a large number of novel, cancer-specific contrast agents that are in early stage clinical trials and preclinical development that demonstrate significant promise to improve real-time detection of subclinical cancer in the operative setting.
