Brain SPECT as an Imaging Biomarker for Evaluating Effects of Novel Treatments in Psychiatry-A Case Series.
Brain SPECT as an Imaging Biomarker for Evaluating Effects of Novel Treatments in Psychiatry-A Case Series.
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DOI：
10.3389/fpsyt.2021.713141
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发表时间：
2021
影响因子：
4.7
通讯作者：
Pavel DG
中科院分区：
文献类型：
--
作者：
Best SRD;Haustrup N;Pavel DG
评估患有复杂神经精神疾病的患者并开具适当治疗处方的困难是众所周知的。成像补充临床评估，并允许临床医生通过促进准确和有效的评估来缩小鉴别诊断。这与经常使用排除的试错过程诊断的神经精神疾病特别相关。单光子发射计算机断层扫描（SPECT）是一种功能性脑成像程序，允许从业者基于局部脑血流（rCBF）测量灰质结构的功能变化。由于复杂的病例和频繁的合并症，精神病学的准确诊断和治疗选择具有挑战性。然而，这种复杂的神经精神疾病越来越多地受益于新的治疗方法，除了既定的药物。其中包括经颅磁刺激与氯胺酮输注（CTK）、高压氧治疗（HBOT）和依那西普（PSE）的脊髓周围给药。本文为读者提供了六个案例研究的例子，展示了如何使用脑SPECT成像，既作为一种诊断工具，也作为一种潜在的生物标志物，用于监测和评估复杂神经精神疾病患者的新治疗方法。在我们的诊所对6名患者进行了评估，并将Tourettes和长期饮酒史的基线脑SPECT图像与CTK或HBOT治疗后收集的SPECT图像进行了视觉比较。这篇回顾性综述展示了这些新疗法的临床效用，并描述了SPECT成像如何补充标准诊断评估。一种新的SPECT图像显示技术的描述，我们认为，SPECT成像可用于监测生物标志物的临床变化。
The difficulties of evaluating patients with complex neuropsychiatric conditions and prescribing appropriate treatments are well known. Imaging complements clinical assessments and allows a clinician to narrow the differential diagnosis by facilitating accurate and efficient evaluation. This is particularly relevant to neuropsychiatric conditions that are often diagnosed using a trial-and error process of exclusion. Single Photon Emission Computed Tomography (SPECT) is a functional brain imaging procedure that allows practitioners to measure the functional changes of gray matter structures based on regional cerebral blood flow (rCBF). The accurate diagnosis and treatment selection in psychiatry is challenging due to complex cases and frequent comorbidities. However, such complex neuropsychiatric conditions are increasingly benefitting from new treatment approaches, in addition to established medications. Among these are combination transcranial magnetic stimulation with ketamine infusions (CTK), hyperbaric oxygen therapy (HBOT) and perispinal administration of etanercept (PSE). This article provides readers with six case study examples that demonstrate how brain SPECT imaging can be used, both as a diagnostic tool, and as a potential biomarker for monitoring and evaluating novel treatments for patients with complex neuropsychiatric conditions. Six patients were assessed in our clinic and baseline brain SPECT imagesTourettes and a long history of alcohol were visually compared with SPECT images collected after periods of treatment with CTK or HBOT followed by PSE. This retrospective review demonstrates the clinical utility of these novel treatments and describes how SPECT imaging can complement standard diagnostic assessments. A novel display technique for SPECT images is described and we argue that SPECT imaging can be used for monitoring biomarker for clinical change.
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DOI：
10.2174/1874440001105010040
发表时间：
2011-01-01
期刊：
The open neuroimaging journal
影响因子：
--
作者：
Amen, Daniel G;Trujillo, Manuel;Chaitin, Barry
通讯作者：
Chaitin, Barry
影响因子：
7
作者：
Guinane, John;Ng, Boon Lung
通讯作者：
Ng, Boon Lung
影响因子：
3.1
作者：
Estudillo-Guerra, Maria Anayali;Pacheco-Barrios, Kevin;Flores-Ramos, Monica
通讯作者：
Flores-Ramos, Monica
影响因子：
4.7
作者：
Escobar, R;Rios, A;Herrera, CP
通讯作者：
Herrera, CP
影响因子：
1.8
作者：
CHANG, LT
通讯作者：
CHANG, LT