Unbiased number of vestibular ganglion neurons in the mouse
Unbiased number of vestibular ganglion neurons in the mouse
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DOI：
10.1016/s0304-3940(98)00241-9
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发表时间：
1998-04-24
影响因子：
2.5
通讯作者：
Guldin, W
中科院分区：
文献类型：
--
作者：
Bäurle, J;Guldin, W
来自迷路和耳石器官的前庭感觉信息仅通过源自前庭神经节 (VG) 神经元的初级前庭传入 (PVA) 传导至中枢神经系统。在本研究中，利用物理解剖器的无偏立体计数方法的原理，确定了两种不同野生型小鼠品系的 VG 神经元总数。 B6CBA 品系的 VG 中存在 3316 个（+/-225 SD）神经元，C57BL/6J 小鼠的 VG 中存在 3551 个（+/-239 SD）神经元。由于两种菌株之间没有检测到统计差异，因此合并的平均数量为 3433 (+/-232 SD) 神经元。这是对 VG 神经元的首次无偏估计，旨在为比较研究以及实验、药理学和病理条件以及衰老对 VG 神经元的存活和维持的影响提供数值基础。 (C) 1998 爱思唯尔科学爱尔兰有限公司
Vestibular sensory information from the labyrinth and otolith organs is conducted to the central nervous system exclusively via primary vestibular afferents (PVA) originating from neurons located in the vestibular ganglion (VG). In the present study, the total number of VG neurons was determined in two different wild-type mouse strains using the principles of unbiased stereological counting methods by means of the physical disector. 3316 (+/-225 SD) neurons were present in the VG of the B6CBA-strain and 3551 (+/-239 SD) in C57BL/6J-mice. Since no statistical difference was detected between the two strains, the pooled mean number was 3433 (+/-232 SD) neurons. This is the first unbiased estimate of VG neurons aimed at providing a numerical basis for comparative studies and for the impact of experimental, pharmacological and pathological conditions as well as ageing on the survival and maintenance of VG neurons. (C) 1998 Elsevier Science Ireland Ltd.