Enflurane Blood‐Gas Solubility: Influence of Weight and Hemoglobin
Enflurane Blood‐Gas Solubility: Influence of Weight and Hemoglobin
复制标题
安氟醚血气溶解度：体重和血红蛋白的影响
作者：
James D. Borel;J. Bentley;R. Vaughan;A. Gandolfi
在9名非肥胖和8名病态肥胖患者中测定了安氟醚的血气分配系数，并将其与体重、体重指数和血红蛋白相关。肥胖患者的安氟醚血气分配系数低于非肥胖患者（平均值± SEM：分别为2.03 ± 0.02和1.76 ± 0.03，p < 0.025）。安氟醚血液溶解度与体重指数和体重呈负相关（r分别为-0.59和-0.55，p < 0.01）。血红蛋白与安氟醚血气分配系数呈正相关（r = 0.69，P < 0.01）。在病态肥胖和贫血患者中，吸入和肺泡安氟醚浓度之间的平衡应快于健康非肥胖患者。
The blood-gas partition coefficient of enflurane was measured in nine nonobese and eight morbidly obese patients and correlated with weight, body mass index, and blood hemoglobin. The enflurane blood-gas partition coefficient was lower in the obese patients than in nonobese patients (mean ± SEM: 2.03 ± 0.02 versus 1.76 ± 0.03, respectively, p < 0.025). There was a negative correlation between enflurane blood solubility and both body mass index and weight (r = −0.59 and −0.55, respectively, p < 0.01). A positive correlation was found between hemoglobin and the enflurane blood-gas partition coefficient (r = 0.69, p < 0.01). Equilibrium between inspired and alveolar enflurane concentration should be faster in morbidly obese and anemic patients than in healthy, nonobese patients.
安氟醚在肥胖患者中的处置。
DOI：
--
发表时间：
1980
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Miller,MS;Gandolfi,AJ;Vaughan,RW;Bentley,JB
通讯作者：
Bentley,JB