COMPARISON OF SHORT-TERM OUTCOME OF LAPAROSCOPIC SLEEVE GASTRECTOMY AND GASTRIC BYPASS IN THE TREATMENT OF MORBID OBESITY: A PROSPECTIVE RANDOMIZED CONTROLLED MULTICENTER SLEEVEPASS STUDY WITH 6-MONTH FOLLOW-UP
COMPARISON OF SHORT-TERM OUTCOME OF LAPAROSCOPIC SLEEVE GASTRECTOMY AND GASTRIC BYPASS IN THE TREATMENT OF MORBID OBESITY: A PROSPECTIVE RANDOMIZED CONTROLLED MULTICENTER SLEEVEPASS STUDY WITH 6-MONTH FOLLOW-UP
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DOI：
10.1177/1457496913509984
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发表时间：
2014-09-01
影响因子：
2.4
通讯作者：
Salminen, P.
中科院分区：
文献类型：
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作者：
Helmio, M.;Victorzon, M.;Salminen, P.
背景和目的：腹腔镜 Roux-en-Y 胃绕道术治疗病态肥胖的长期疗效已得到证实。腹腔镜袖状胃切除术已显示出有希望的短期结果，但长期疗效仍不清楚。这项前瞻性随机多中心研究的目的是比较 Roux-en-Y 胃绕道术和袖状胃切除术的结果。 材料和方法：总共 240 名病态肥胖患者被随机分配接受 Roux-en-Y 胃绕道术或袖状胃切除术。研究的主要终点是体重减轻，次要终点是合并症和发病率的解决。分析 6 个月时的短期结果。 结果：袖状胃切除术组 6 个月时的平均超重减轻率为 49.2%，Roux-en-Y 胃绕道手术组为 52.9%（p = 0.086）。袖状胃切除术组中 84.3% 的患者和 Roux-en-Y 胃绕道手术组中 93.3% 的患者的 2 型糖尿病得到缓解或改善 (p = 0.585)。动脉高血压的相应结果分别为 76.8% 和 81.9% (p = 0.707)，高胆固醇血症的相应结果分别为 64.1% 和 69.0% (p = 0.485)。 6个月时没有死亡。袖状胃切除术后出现一项主要并发症，Roux-en-Y 胃绕道术后出现两项主要并发症 (p = 0.531)。 8 例袖状胃切除术患者和 11 例 Roux-en-Y 胃绕道术患者出现轻微并发症（p = 0.403）。结论：袖状胃切除术和 Roux-en-Y 胃绕道术在体重减轻、肥胖相关合并症和并发症消退方面的短期结果在 6 个月时没有差异。
Background and Aims: The long-term efficacy of laparoscopic Roux-en-Y gastric bypass in the treatment of morbid obesity has already been demonstrated. Laparoscopic sleeve gastrectomy has shown promising short-term results, but the long-term efficacy is still unclear. The aim of this prospective randomized multicenter study is to compare the results of Roux-en-Y gastric bypass and sleeve gastrectomy.Material and Methods: A total of 240 morbidly obese patients were randomized to undergo either Roux-en-Y gastric bypass or sleeve gastrectomy. The primary end point of study was weight loss, and the secondary end points were resolution of comorbidities and morbidity. The short-term results at 6 months were analyzed.Results: The mean excess weight loss at 6 months was 49.2% in the sleeve gastrectomy group and 52.9% in the Roux-en-Y gastric bypass group (p = 0.086). Type 2 diabetes was resolved or improved in 84.3% of patients in the sleeve gastrectomy group and 93.3% in the Roux-en-Y gastric bypass group (p = 0.585). The corresponding results for arterial hypertension were 76.8% and 81.9% (p = 0.707) and for hypercholesterolemia 64.1% and 69.0% (p = 0.485). There was no mortality at 6 months. There was one major complication following sleeve gastrectomy and two after Roux-en-Y gastric bypass (p = 0.531). Eight sleeve gastrectomy patients and 11 Roux-en-Y gastric bypass patients had minor complications (p = 0.403).Conclusion: The short-term results of sleeve gastrectomy and Roux-en-Y gastric bypass regarding weight loss, resolution of obesity-related comorbidities and complications were not different at 6 months.