Plasma elevations of histamine and a prostaglandin metabolite in acute asthma.
Plasma elevations of histamine and a prostaglandin metabolite in acute asthma.
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急性哮喘中组胺和前列腺素代谢物的血浆升高。
DOI：
10.1164/ajrccm/137.5.1009
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
P. Fireman
中科院分区：
文献类型：
--
作者：
David Skoner;R. Page;B. Åsman;L. Gillen;P. Fireman
最近的实验室诱发哮喘的研究表明，哮喘是一种下呼吸道的炎症性疾病。本研究的目的是利用前瞻性、连续采样方案，测量自然获得性急性哮喘期间2种支气管收缩炎症介质的系统性阐述。本文用放射免疫法和放射酶法分别测定了23例急性哮喘患儿血浆13，14-二氢-15-酮-前列腺素F_（2 α）和组胺水平。给药前平均PG代谢物和组胺值（pg/ml）（167 +/- 72，1，029 +/- 378）和10至90分钟后（377 +/- 145，1，000 +/- 489）的初始治疗显著高于哮喘缓解后的相同儿童（2.9 ± 0.2，260 ± 42）和正常儿童（4.3 ± 0.9，240 ± 14）。表现出PEFR值的儿童的PG代谢物峰值水平显著更高（%预测值）小于40%（1，234 +/- 432）与那些呈现大于40%的人相比（404 +/- 296），以及治疗后PEFR改善小于20%的儿童（1，281 +/- 470）与大于20%（365 +/- 226）相比。治疗后PEFR改善小于20%的儿童（2，560 +/-1，600）的组胺水平显著高于治疗后PEFR改善大于20%的儿童（475 +/- 100），住院儿童（3，915 +/-1，910）的组胺水平显著高于非住院儿童（408 +/- 130）的组胺水平。在皮质类固醇依赖、过敏倾向或初始治疗类型的基础上未观察到显著差异。这些数据表明组胺和PGF 2 α在急性哮喘气道炎症发病机制中的作用。
Recent studies of laboratory-provoked asthma have suggested that asthma is an inflammatory disease of lower airways. The purpose of this study was to measure the systemic elaboration of 2 bronchoconstrictive inflammatory mediators during naturally acquired acute asthma utilizing a prospective, serial-sampling protocol. Plasma levels of 13,14-dihydro-15-keto-PGF2 alpha and histamine were measured by radioimmunoassay and radioenzymatic assay, respectively, in 23 children with acute asthma. Mean PG metabolite and histamine values (pg/ml) before (167 +/- 72, 1,029 +/- 378) and 10 to 90 min after (377 +/- 145, 1,000 +/- 489) initial therapy were significantly higher than those of the same children after resolution of asthma (2.9 +/- 0.2, 260 +/- 42) and those of normal children (4.3 +/- 0.9, 240 +/- 14). Peak PG metabolite levels were significantly higher in children who presented with PEFR values (% predicted) less than 40% (1,234 +/- 432) compared with those who presented with greater than 40% (404 +/- 296), and in children with post-therapy improvement in PEFR of less than 20% (1,281 +/- 470) compared with those with greater than 20% (365 +/- 226). Histamine levels were significantly higher in children with post-therapy improvement in PEFR of less than 20% (2,560 +/- 1,600) compared with those with greater than 20% (475 +/- 100), and in hospitalized (3,915 +/- 1,910) compared with nonhospitalized (408 +/- 130) children. Significant differences were not observed on the basis of corticosteroid dependence, allergic disposition, or type of initial therapy. These data suggest a role for histamine and PGF2 alpha in the pathogenesis of airway inflammation in acute asthma.
组胺的测量：质量控制研究。
DOI：
10.1016/0091-6749(80)90024-x
发表时间：
1980
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Gleich,GJ;Hull,WM
通讯作者：
Hull,WM