Cortactin localization in actin-containing adult and fetal tissues
Cortactin localization in actin-containing adult and fetal tissues
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DOI：
10.1177/002215549804601011
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发表时间：
1998-10-01
影响因子：
3.2
通讯作者：
Montone, KT
中科院分区：
文献类型：
--
作者：
Wu, H;Montone, KT
皮质蛋白是一种酪氨酸激酶底物，与丝状肌动蛋白结合。它代表了一个高度保守的膜周围信号蛋白家族。人类的皮质蛋白同源物是由基因EMS1编码的，该基因在一些人类乳腺癌、头颈癌中被扩增。本研究表明，接触优先定位于极化上皮的顶端表面，特别是小肠上皮的终网和近端肾小管、甲状腺滤泡和细支气管上皮的顶端表面。在具有肌动蛋白为基础的收缩能力的细胞和组织类型中，包括平滑肌、横纹肌和肌上皮中，也可见皮质。
Cortactin is a tyrosine kinase substrate that binds to filamentous actin. It represents a highly conserved family of perimembrane signaling proteins. The human homologue of cortactin is encoded by gene EMS1, which is amplified in some human breast, head, and neck carcinomas. This study shows that cortactin is preferentially localized to the apical surfaces of the polarized epithelium, specifically, to the terminal web of small bower epithelium and to apical surfaces of the proximal renal tubules, thyroid follicles, and bronchiolar epithelium. Cortactin is also seen in cell and tissue types with actin-based contractile capacities, including smooth and striated muscle and myoepithelium.