Abnormal affective decision making revealed in adolescent binge drinkers using a functional magnetic resonance imaging study.
Abnormal affective decision making revealed in adolescent binge drinkers using a functional magnetic resonance imaging study.
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DOI：
10.1037/a0027892
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发表时间：
2013-06
期刊：
影响因子：
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通讯作者：
Lin Xiao;A. Bechara;Q. Gong;Xiaoqi Huang;Xiangrui Li;G. Xue;S. Wong;Zhonglin Lu;P. Palmer;Yonglan Wei;Yong Jia;C. Johnson
中科院分区：
文献类型：
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作者：
Lin Xiao;A. Bechara;Q. Gong;Xiaoqi Huang;Xiangrui Li;G. Xue;S. Wong;Zhonglin Lu;P. Palmer;Yonglan Wei;Yong Jia;C. Johnson
这项研究的目的是调查情感决策的神经相关性，根据爱荷华州赌博任务(IGT)的测量，这与青少年酗酒有关。中国，从成都当地高中招募了14名青少年酗酒者(16-18岁)和14名年龄匹配的从未饮酒的青少年。调查问卷被用来评估学习成绩、饮酒经历和紧迫感。通过功能磁共振成像识别IGT表现所激活的脑区。结果表明，与从不饮酒的人相比，酗酒者在IGT上的表现更差，在与执行情绪和激励相关行为有关的决策神经回路的亚成分中表现出更高的活性，即左侧杏仁核和双侧岛叶。此外，对现实生活中饮酒问题严重程度的衡量，以及高紧迫感分数，都与脑岛内活动的增加和眼眶额叶皮质内的活动减少有关。这些结果表明，与情绪和激励相关行为的执行有关的神经系统的高反应性可能与青少年中的社交不受欢迎的行为有关，如酗酒。这些发现具有社会意义，因为它们潜在地揭示了做出糟糕决定的潜在神经机制，这可能会增加个人酗酒的风险和脆弱性。
The goal of this study was to investigate the neural correlates of affective decision making, as measured by the Iowa Gambling Task (IGT), which are associated with adolescent binge drinking. Fourteen adolescent binge drinkers (16-18 years of age) and 14 age-matched adolescents who had never consumed alcohol--never drinkers--were recruited from local high schools in Chengdu, China. Questionnaires were used to assess academic performance, drinking experience, and urgency. Brain regions activated by the IGT performance were identified with functional magnetic resonance imaging. Results showed that, compared to never drinkers, binge drinkers performed worse on the IGT and showed higher activity in the subcomponents of the decision-making neural circuitry implicated in the execution of emotional and incentive-related behaviors, namely, the left amygdala and insula bilaterally. Moreover, measures of the severity of drinking problems in real life, as well as high urgency scores, were associated with increased activity within the insula, combined with decreased activity within the orbitofrontal cortex. These results suggest that hyperreactivity of a neural system implicated in the execution of emotional and incentive-related behaviors can be associated with socially undesirable behaviors, such as binge drinking, among adolescents. These findings have social implications because they potentially reveal underlying neural mechanisms for making poor decisions, which may increase an individual's risk and vulnerability for alcoholism.