Bone marrow-derived cells: A potential approach for the treatment of xerostomia
Bone marrow-derived cells: A potential approach for the treatment of xerostomia
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DOI：
10.1016/j.biocel.2010.10.010
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Khalili, Saeed
中科院分区：
文献类型：
--
作者：
Tran, Simon D.;Sumita, Yoshinori;Khalili, Saeed
骨髓来源细胞(BMDCs)的移植传统上用于血液病，但使用BMDC治疗包括自身免疫性疾病在内的非血液病的临床试验越来越多。最近有报道称，骨髓基质细胞可以改善器官功能。这篇文章将综述现有的支持BMDCs在减少因头颈部放射治疗癌症和干燥综合征引起的口干症(即重建唾液腺功能)方面的作用的报告。有报道称，BMDCs对唾液的产生有有益的影响。BMDCs对照射后唾液腺的血管稳定性和再生有积极作用。此外，BMDCs还为患有干燥样疾病的小鼠提供了免疫调节活性。尽管BMDCs改善器官功能的确切机制仍然存在争议，但初步证据表明，它们的组合(如细胞转分化、血管生成和旁分泌效应)发生在唾液腺中。(C)2010爱思唯尔有限公司。保留所有权利。
Transplantations of bone marrow-derived cells (BMDCs) are traditionally used for hematologic diseases, but there are increasing numbers of clinical trials using BMDC treatments for non-hematologic disorders, including autoimmune diseases. BMDCs are recently reported to improve organ functions. This paper will review available reports supporting the role of BMDCs in reducing xerostomia (i.e. re-establishing salivary gland functions) due to head and neck irradiation for cancer therapies and in Sjogren's syndrome. There are reports that BMDCs provide a beneficial effect on the saliva production. BMDCs positively affect blood vessels stability and regeneration in irradiated salivary glands. Also, BMDCs provide an immunomodulatory activity in mice with Sjogren's-like disease. While the exact mechanisms by which BMDCs improve organ functions remain controversial, there is preliminary evidence that a combination of them (such as cell transdifferentiation, vasculogenesis, and paracrine effect) occur in salivary glands. (C) 2010 Elsevier Ltd. All rights reserved.