Evaluating Osteogenic Differentiation of Osteoblastic Precursors Upon Intermittent Administration of PTH/IGFBP7.
Evaluating Osteogenic Differentiation of Osteoblastic Precursors Upon Intermittent Administration of PTH/IGFBP7.
复制标题
间歇性施用 PTH/IGFBP7 后评估成骨细胞前体的成骨分化
DOI：
10.3389/fphar.2022.839035
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发表时间：
2022
影响因子：
5.6
通讯作者：
Xue, Yuan
中科院分区：
文献类型：
--
作者：
Xia, Han;Tian, Yueyang;Lin, Yile;Huang, Qia;Xue, Yuan
甲状旁腺激素（PTH）1-34是第一个被批准用于治疗骨质疏松症的合成代谢药物。临床前证据显示PTH和骨肉瘤之间存在潜在关联。目前对PTH的骨形成和肿瘤形成机制的研究尚不完全清楚，关于胰岛素样生长因子结合蛋白7（IGFBP 7）在PTH合成代谢中的作用的研究报道较少。发现间歇性PTH给药增加间充质干细胞（MSC）和成骨细胞前体中IGFBP 7的表达。结果表明，当IGFBP 7敲低时，PTH的合成代谢作用被中断，而补充IGFBP 7蛋白可以增强PTH的成骨功效并调节信号通路。此外，在骨折的小鼠模型中，通过与PTH沿着施用IGFBP 7加速了骨愈合。由此可知，IGFBP 7是PTH的合成代谢作用所必需的，与单独给予PTH相比，联合给予PTH和IGFBP 7显示出更强的骨形成作用。
Parathyroid hormone (PTH) 1–34 is the first anabolic agent approved for the treatment of osteoporosis. Preclinical evidence shows a potential association between PTH and osteosarcoma. The mechanisms mediating the bone- and neoplasm-forming effects of PTH remain incompleted understood, few studies on the role of Insulin-like growth factor-binding protein 7 (IGFBP7) in mediating the anabolic effects of PTH has been reported. Intermittent PTH administration was found to increase the expression of IGFBP7 in mesenchymal stem cells (MSCs) and pre-osteoblasts. The results indicated that the anabolic effects of PTH were interrupted when knockdown of IGFBP7, while supplementation with IGFBP7 protein could enhance the bone-forming efficacy of PTH and regulate the signaling pathways. Moreover, bone healing was accelerated by the administration of IGFBP7 along with PTH in a mouse model of fracture. The obtained results proved that IGFBP7 was necessary for the anabolic effects of PTH, and combined administration of PTH and IGFBP7 showed stronger bone-forming effects relative to administration of PTH alone.
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影响因子：
9
作者：
Verhagen HJ;de Leeuw DC;Roemer MG;Denkers F;Pouwels W;Rutten A;Celie PH;Ossenkoppele GJ;Schuurhuis GJ;Smit L
通讯作者：
Smit L
影响因子：
11.2
作者：
Akiel M;Guo C;Li X;Rajasekaran D;Mendoza RG;Robertson CL;Jariwala N;Yuan F;Subler MA;Windle J;Garcia DK;Lai Z;Chen HH;Chen Y;Giashuddin S;Fisher PB;Wang XY;Sarkar D
通讯作者：
Sarkar D
影响因子：
4.1
作者：
Eriksen, Erik Fink;Brown, Jacques P.
通讯作者：
Brown, Jacques P.
影响因子：
5.4
作者：
Wein, Marc N.;Kronenberg, Henry M.
通讯作者：
Kronenberg, Henry M.
维生素 K2 和 PTH 联合治疗可增强去势大鼠的骨形成并增加体外成骨细胞的分化
影响因子：
5.1
作者：
Weng, She-Ji;Yan, De-Yi;Yang, Lei
通讯作者：
Yang, Lei