Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection
Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection
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泰勒病毒引起的脱髓鞘病变与持续的中枢神经系统感染有关
作者：
M. Chamorro;C. Aubert;M. Brahic
我们使用原位杂交和免疫细胞化学来寻找病毒表达和白质损害之间的相关性，在由于持续的泰勒氏病毒感染引起的晚期脱髓鞘疾病中。我们发现了以下内容。(I)在病毒感染部位形成的组织损害。这种相关性不能用淋巴细胞和巨噬细胞的感染来解释。(Ii)小鼠之间的病理程度存在很大差异。炎症的数量与含有病毒RNA或病毒衣壳抗原的细胞数量成正比。(Iii)抵抗脱髓鞘的C57BL/6小鼠能够根除感染。我们的结果强烈支持病毒基因产物发挥核心作用的脱髓鞘机制。
We used in situ hybridization and immunocytochemistry to look for a correlation between virus expression and white matter lesions during late demyelinating disease due to persistent Theiler's virus infection. We found the following. (i) Tissue lesions developed at the site of virus infection. This correlation was not explained by infection of lymphocytes and macrophages. (ii) Large differences in the extent of pathology existed between mice. The amount of inflammation paralleled the number of cells containing viral RNA or viral capsid antigens. (iii) C57BL/6 mice, which are resistant to demyelination, were able to eradicate the infection. Our results are strongly in favor of a mechanism of demyelination in which viral gene products play a central role.