Polypeptide activators of cholesterol side-chain cleavage.
Polypeptide activators of cholesterol side-chain cleavage.
复制标题
胆固醇侧链裂解的多肽激活剂。
DOI：
10.1080/07435808409036515
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发表时间：
1984
影响因子：
2.1
通讯作者：
Pedersen,RC
中科院分区：
文献类型：
--
作者：
Pedersen,RC
A rate-determining step in the cAMP-dependent action of ACTH on adrenal steroid biosynthesis is the interaction of cholesterol substrate with the cholesterol side-chain cleavage cytochrome P-450 in the mitochondrion. This interaction is rapidly and reversibly sensitive to inhibitors of protein synthesis. For this reason a hormone-dependent, labile protein activator of cholesterol side-chain cleavage has long been postulated as an obligatory intermediate in the tropic regulation of this reaction. Applying recent advances in liquid chromatography, two-dimensional gel electrophoresis, and enzyme reconstitution into liposomes, several laboratories have now reported the isolation and partial characterization of polypeptide candidates for the status of “labile protein.“
