Staphylococcus aureus:: A well-armed pathogen
Staphylococcus aureus:: A well-armed pathogen
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DOI：
10.1086/520289
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发表时间：
1998-05-01
影响因子：
11.8
通讯作者：
Archer, GL
中科院分区：
文献类型：
--
作者：
Archer, GL
金黄色葡萄球菌是一种致命的病原体，目前是住院患者感染的最常见原因。S.金黄色葡萄球菌感染可累及任何器官系统。金黄色葡萄球菌作为病原体及其引起如此广泛的感染的能力是其广泛的毒力因子的结果。这种毒力病原体对抗菌剂的抗性的增加，连同其作为医院病原体的日益普遍，是主要关注的问题。核心抗性表型似乎与S.金黄色葡萄球菌在医院是耐甲氧西林。医院内沙门氏菌的甲氧西林耐药性。金黄色葡萄球菌分离株在美国医院中急剧增加，并且还与对其他有用的抗葡萄球菌化合物的耐药性有关。金黄色葡萄球菌感染的研究包括建立更有效的感染控制、减少鼻定植、开发疫苗和开发新的或改进的抗微生物剂。
Staphylococcus aureus is a virulent pathogen that is currently the most common cause of infections in hospitalized patients. S. aureus infection can involve any organ system, The success of S. aureus as a pathogen and its ability to cause such a wide range of infections are the result of its extensive virulence factors, The increase in the resistance of this virulent pathogen to antibacterial agents, coupled with its increasing prevalence as a nosocomial pathogen, is of major concern. The core resistance phenotype that seems to be most associated with the persistence of S. aureus in the hospital is methicillin resistance. Methicillin resistance in nosocomial S. aureus isolates has been increasing dramatically in United States hospitals and is also associated with resistance to other useful antistaphylococcal compounds, Possible ways to decrease the incidence of nosocomial S. aureus infections include instituting more effective infection control, decreasing nasal colonization, developing vaccines, and developing new or improved antimicrobials.