Combat blast related traumatic brain injury (TBI): Decade of recognition; promise of progress
Combat blast related traumatic brain injury (TBI): Decade of recognition; promise of progress
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DOI：
10.1016/j.bbr.2016.08.036
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发表时间：
2018-03-15
影响因子：
2.7
通讯作者：
Hoffman, Stuart W.
中科院分区：
文献类型：
--
作者：
DePalma, Ralph G. ae;Hoffman, Stuart W.
2007年4月至2015年12月期间，退伍军人健康管理局（VHA）在“持久自由”、“伊拉克自由”和“新黎明”行动（OEF/OIF/OND）期间部署的260万名退伍军人中筛查了100万名创伤性脑损伤（TB!）。自2007年以来，在那些报告、筛选和推荐进行最终评估的退伍军人中，大约8.4%的人被诊断为TBI，其中大多数为mTBI/脑震荡（mTBI），并且很大一部分与爆炸暴露有关。轻度创伤性脑损伤被称为“标志性损伤”，也被称为这些冲突的“隐形损伤”。识别和评估mTBI的神经病理学、细胞和由此产生的认知、情感、行为和神经学后果，构成了巨大的临床和研究挑战。我们简要概述了当前的历史，与爆炸暴露相关的损伤机制，协调研究支持，以及了解爆炸损伤（特别是mTBI）发生的特定细胞和神经变化的必要性。Elsevier B.V.出版
Between April 2007 and December 2015, the Veterans Health Administration (VHA) screened one million combat veterans for traumatic brain injury (TB!), among 2.6 million deployed during operations Enduring Freedom, Iraqi Freedom and New Dawn (OEF/OIF/OND). Since 2007, among those reporting, screened and referred for definitive evaluation, approximately 8.4% of these Veterans received a diagnosis of TBI, the majority characterized as mTBI/Concussion (mTBI) and, in great proportion, related to blast exposures. Mild Traumatic brain injury called "a signature injury" is also known as 'the invisible injury' of these conflicts. Identifying and assessing neuropathological, cellular and resulting cognitive, emotional, behavioral and neurological consequences of mTBI comprise vast clinical and research challenges. We provide a brief overview of current history, injury mechanisms related to blast exposure, coordinated research support, and the need to understand specific cellular and neurological changes occurring with blast injury, particularly mTBI. Published by Elsevier B.V.