FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
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DOI：
10.1016/j.jhep.2013.08.005
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发表时间：
2013-12-01
影响因子：
25.7
通讯作者：
Gotthardt, Daniel Nils
中科院分区：
文献类型：
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作者：
Wannhoff, Andreas;Hov, Johannes Roksund;Gotthardt, Daniel Nils
背景与目的：岩藻糖基转移酶2和3(FUT2/3)的等位基因变异会影响血清CA19-9水平，CA19-9是PSC中检测胆道恶性肿瘤的常用筛查指标。方法：检测433例PSC患者血清CA19-9水平，其中41例为胆道恶性肿瘤。根据FUT3和FUT2的基因分型将患者分为三组：A组，无论FUT2活性如何，都没有FUT3活性；B，FUT2和FUT3都有活性；C，没有FUT2活性但没有FUT3活性。结果：两组间CA19-9中位数差异有统计学意义(P<0.05)。
Background & Aims: Allelic variants of fucosyltransferases 2 and 3 (FUT2/3) influence serum levels of CA19-9, a screening parameter commonly used for detection of biliary malignancy in PSC. We aimed at improving diagnostic accuracy of CA19-9 by determining the impact of FUT2/3 genotypes.Methods: CA19-9 levels were measured in 433 PSC patients, 41 of whom had biliary malignancy. Genotypes for FUT3 and FUT2 were used to assign patients to one of three groups: A, no FUT3 activity regardless of FUT2 activity; B, both FUT2 and FUT3 activity and C, no FUT2 activity without loss of FUT3 activity. Group-specific cut-off values were determined by Youden's index.Results: The median CA19-9 values of cancer-free patients were significantly different (p