Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold
Chromatin silencing protein and pachytene checkpoint regulator Dot1p has a methyltransferase fold
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DOI：
10.1016/s0968-0004(01)01856-4
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发表时间：
2001-07-01
影响因子：
13.8
通讯作者：
Dlakic, M
中科院分区：
文献类型：
--
作者：
Dlakic, M
虽然蛋白质甲基化已经被观察了几十年，但它的功能意义在很大程度上仍然不清楚。通过敏感图谱搜索和结构模拟，将染色质沉默蛋白和减数分裂重组检查点调节因子Dot1p鉴定为一种可能的蛋白质甲基转移酶。连同最近将组蛋白H3甲基化与染色质沉默联系在一起的结果，这一发现表明，蛋白质修饰的扩展组合谱系影响转录调节。
Although protein methylation has been observed for decades, its functional significance has remained largely unclear. Using sensitive profile searches and structural modeling, chromatin silencing protein and meiotic recombination checkpoint regulator Dot1p was identified as a putative protein methyltransferase. Along with recent results that link histone H3 methylation with chromatin silencing, this finding suggests that an expanded combinatorial repertoire of protein modifications affects transcriptional regulation.