Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes.
Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes.
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DOI：
10.1021/nn900368b
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发表时间：
2009-09-22
期刊：
影响因子：
17.1
通讯作者：
Gmeiner WH
中科院分区：
文献类型：
--
作者：
Ghosh S;Dutta S;Gomes E;Carroll D;D'Agostino R Jr;Olson J;Guthold M;Gmeiner WH
纳米颗粒，包括多壁碳纳米管（MWNT），强烈吸收近红外（nIR）辐射，并有效地将吸收的能量转化为释放的热量，可用于局部热疗应用。我们第一次证明了DNA包裹增加了多壁碳纳米管的近红外辐射后的热发射，并且DNA包裹的多壁碳纳米管可用于安全地根除体内肿瘤块。DNA包裹的多壁碳纳米管照射后，产生的热量与照射时间和激光功率呈线性关系。DNA包封导致本体溶液温度增加10 °C所需的MWNT浓度降低3倍。单次治疗包括瘤内注射MWNT（100 μL 500 μg/mL溶液），然后在1064 nm、2.5 W/cm 2下进行激光照射，在8/8（100%）裸鼠中完全根除了PC 3异种移植瘤。仅接受MWNT注射或激光照射的肿瘤显示出与未治疗的对照肿瘤无区别的生长速率。非恶性组织未显示出治疗的长期损伤。结果表明，DNA包裹的多壁碳纳米管是更有效地将nIR辐射转化为热量相比，nonencrypted的多壁碳纳米管和DNA包裹的多壁碳纳米管可以安全有效地用于选择性热消融的恶性组织在体内。
Nanoparticles, including multiwalled carbon nanotubes (MWNTs), strongly absorb near-infrared (nIR) radiation and efficiently convert absorbed energy to released heat which can be used for localized hyperthermia applications. We demonstrate for the first time that DNA-encasement increases heat emission following nIR irradiation of MWNTs, and DNA-encased MWNTs can be used to safely eradicate a tumor mass in vivo. Upon irradiation of DNA-encased MWNTs, heat is generated with a linear dependence on irradiation time and laser power. DNA-encasement resulted in a 3-fold reduction in the concentration of MWNTs required to impart a 10 °C temperature increase in bulk solution temperature. A single treatment consisting of intratumoral injection of MWNTs (100 μL of a 500 μg/mL solution) followed by laser irradiation at 1064 nm, 2.5 W/cm2 completely eradicated PC3 xenograft tumors in 8/8 (100%) of nude mice. Tumors that received only MWNT injection or laser irradiation showed growth rates indistinguishable from nontreated control tumors. Nonmalignant tissues displayed no long-term damage from treatment. The results demonstrate that DNA-encased MWNTs are more efficient at converting nIR irradiation into heat compared to nonencased MWNTs and that DNA-encased MWNTs can be used safely and effectively for the selective thermal ablation of malignant tissue in vivo.
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影响因子：
17.1
作者：
Bhirde, Ashwin A.;Patel, Vyomesh;Gavard, Julie;Zhang, Guofeng;Sousa, Alioscka A.;Masedunskas, Andrius;Leapman, Richard D.;Weigert, Roberto;Gutkind, J. Silvio;Rusling, James F.
通讯作者：
Rusling, James F.
影响因子：
10.8
作者：
Hughes, Mary E.;Brandin, Eric;Golovchenko, Jene A.
通讯作者：
Golovchenko, Jene A.
影响因子：
51.1
作者：
Lencioni, Riccardo;Crocetti, Laura;Mussi, Alfredo
通讯作者：
Mussi, Alfredo
影响因子：
3.8
作者：
He, XM;Wolkers, WF;Bischof, JC
通讯作者：
Bischof, JC
影响因子：
41.2
作者：
Zheng, M;Jagota, A;Tassi, NG
通讯作者：
Tassi, NG