Consensus opinion from the antibody working group on the diagnosis, reporting, and risk assessment for antibody-mediated rejection and desensitization protocols
Consensus opinion from the antibody working group on the diagnosis, reporting, and risk assessment for antibody-mediated rejection and desensitization protocols
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DOI：
10.1097/01.tp.0000129256.84027.d6
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发表时间：
2004-07-27
期刊：
影响因子：
6.2
通讯作者：
Zachary, AA
中科院分区：
文献类型：
--
作者：
Montgomery, RA;Hardy, MA;Zachary, AA
在过去的几十年里，实体器官移植的大部分实验和临床努力都指向改善或废除T细胞介导的反应。因此，普遍理解和接受的命名和诊断标准已经演变。移植中的体液免疫尚未经历类似的复兴。移植杂志的读者经常发现很难解释抗体介导的排斥反应的诊断和处理的数据，而且往往是不可能的。抗体工作组的成立是为了为命名、诊断标准、报告、抗体分析和风险评估的标准化提供指导方针。关键词：抗体介导的排斥反应、人类白细胞抗原特异性抗体、血浆置换、静脉注射免疫球蛋白。
During the past few decades, much of the experimental and clinical effort in solid-organ transplantation has been directed toward ameliorating or abrogating T-cell-mediated responses. As a result, universally understood and accepted nomenclature and diagnostic criteria have evolved. Humoral immunity in transplantation has yet to undergo a similar renaissance. Readers of transplant journals regularly find it difficult and often impossible to interpret data on the diagnosis and management of antibody-mediated rejection. The Antibody Working Group was assembled in an attempt to provide guidelines for the standardization of nomenclature, diagnostic criteria, reporting, antibody profiling, and risk assessment. Keywords: Antibody-mediated rejection, HLA-specific antibody, plasmapheresis, intravenous immunoglobulin.