Survival analysis of 205 patients with glioblastoma multiforme: Clinical characteristics, treatment and prognosis in China
Survival analysis of 205 patients with glioblastoma multiforme: Clinical characteristics, treatment and prognosis in China
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中国205例多形性胶质母细胞瘤患者的生存分析：临床特征、治疗和预后
DOI：
10.1016/j.jocn.2009.02.036
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发表时间：
2009-12-01
影响因子：
2
通讯作者：
Li, Xingang
中科院分区：
文献类型：
--
作者：
Ma, Xiangyu;Lv, Yafeng;Li, Xingang
为探讨中国多形性胶质母细胞瘤（GBM）的临床特点、治疗和预后，我们回顾性分析了205例经病理证实的GBM患者。对生存时间的预后因素进行单因素分析，并使用考克斯回归方法在多因素分析中检验显著因素。中位总生存时间为12.0个月（95%置信区间[CI] 11.0-13.1个月）。诊断后6个月的生存率为82%，12个月为52%，18个月为27%，24个月为17%。年龄，术前Karnofsky的性能状态评分和肿瘤的位置是独立的术前预后的预测因素，GBM的治疗方法，放疗是最强的预后预测因素，其次是根治性手术和化疗。中国患者诊断后的中位生存时间与西方患者中观察到的11.0-15.9个月范围相当。这些数据表明，中国和西方患者的GBM预后缺乏种族差异。皇冠版权所有（C）2009由爱思唯尔有限公司出版。保留所有权利。
To study the clinical characteristics, treatment and prognosis of patients with glioblastoma multiforme (GBM) in China, we retrospectively analyzed 205 Chinese patients with histologically proven GBM. A univariate analysis of prognosis factors for survival time was performed and significant factors were tested in a multivariate analysis using the Cox regression method. Median overall survival time was 12.0 months (95% confidence interval [CI] 11.0-13.1 months). Survival rates after diagnosis were 82% at 6 months, 52% at 12 months, 27% at 18 months and 17% at 24 months. Age, preoperative Karnofsky's performance status score and tumour location were independent preoperative predictors of prognosis and among the treatment methods of GBM, radiotherapy was the strongest predictor of prognosis followed by radical surgery and chemotherapy. The median survival time post diagnosis for Chinese patients is comparable to the 11.0-15.9 month range observed in western patients. The data suggest a lack of ethnic differences in GBM prognosis of Chinese and western patients. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.