THERMAL HYPERALGESIA ACCELERATES AND MK-801 PREVENTS THE DEVELOPMENT OF TACHYPHYLAXIS TO RAT SCIATIC-NERVE BLOCKADE
THERMAL HYPERALGESIA ACCELERATES AND MK-801 PREVENTS THE DEVELOPMENT OF TACHYPHYLAXIS TO RAT SCIATIC-NERVE BLOCKADE
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DOI：
10.1097/00000542-199411000-00024
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发表时间：
1994-11-01
期刊：
影响因子：
8.8
通讯作者：
BERDE, CB
中科院分区：
文献类型：
--
作者：
LEE, KC;WILDER, RT;BERDE, CB
背景：局麻药的快速耐受性可通过两次注射之间较长的镇痛间隔来促进。我们假设热痛觉过敏也会加速快速耐受的发展。N-甲基-D-天冬氨酸拮抗剂（（+）-5甲基-10，11-二氢-5H-二苯并（a，d）环庚烯-5，10-亚胺，或地佐环平）（MK-801）已被证明可预防热痛觉过敏。因此，我们还假设，MK-801将防止tachyphylaxis.Methods：导管手术植入大鼠沿着坐骨神经。在恢复并适应测试模式后，他们接受了利多卡因或2-氯普鲁卡因的重复注射，然后在48、52或56 ℃下进行运动阻滞测试，有或没有热板测试。在其他实验中，MK-801或生理盐水通过腹膜内注射坐骨神经局部麻醉剂注射和感觉和运动testing.Results：大鼠接受反复利多卡因或2-氯普鲁卡因注射，当反复进行热板测试在56摄氏度，开发热痛觉过敏和快速耐受运动和感觉阻滞。接受无热板暴露或48 ℃热板暴露的大鼠没有发生快速耐受或痛觉过敏。在52摄氏度测试的大鼠比在56摄氏度测试的大鼠产生更轻微的痛觉过敏和更慢的快速耐受。对照实验排除了由于昼夜节律、注射量和学习引起的伪影。MK-801预处理的大鼠在一系列的三个injection.Conclusions：热痛觉过敏加速快速耐受大鼠坐骨神经阻滞的发展，MK-801防止在这个模型中的快速耐受。N-甲基-D-天冬氨酸受体拮抗剂可能在延长局部麻醉剂给药的有效性持续时间方面具有未来的临床实用性。
Background: Tachyphylaxis to local anesthetics has been shown to be promoted by longer interanalgesic intervals between een injections. We hypothesized that thermal hyperalgesia also would accelerate the development of tachyphylaxis. The n-methyl-D-aspartate antagonist ((+)-5 methyl-10,11-dihydro- 5H-dibenzo (a,d) cyclohepten-5,10-imine, or dizocilpine) (MK-801) has been shown to prevent thermal hyperalgesia. We therefore also hypothesized that MK-801 would prevent tachyphylaxis.Methods: Catheters were surgically implanted in rats along the sciatic nerve. After recovery and conditioning to the testing paradigm, they received repeated injections of lidocaine or 2-chloroprocaine followed by motor block testing with or without hot-plate testing at 48, 52, or 56 degrees C. In other experiments, MK-801 or saline was administered by intraperitoneal injection before sciatic nerve local anesthetic injection and sensory and motor testing.Results: Rats receiving repeated lidocaine or 2-chloroprocaine injections, when repeatedly subjected to hot-plate testing at 56 degrees C, developed thermal hyperalgesia and tachyphylaxis to motor and sensory blockade. Rats receiving either no hotplate exposure or hot-plate exposure at 48 degrees C developed no tachyphylaxis or hyperalgesia. Rats tested at 52 degrees C developed milder hyperalgesia and developed tachyphylaxis more slowly than did rats tested at 56 degrees C. Control experiments excluded artifacts due to circadian rhythm, injection volume, and learning. Rats pretreated with MK-801 showed no tachyphylaxis over a series of three injections.Conclusions: Thermal hyperalgesia accelerates the development of tachyphylaxis to rat sciatic nerve blockade, and MK-801 prevents tachyphylaxis in this model. n-Methyl-D-aspartate receptor antagonists may have future clinical utility in increasing the duration of effectiveness of prolonged local anesthetic administration.