Heat shock protein 70 delays gentamicin-induced vestibular hair cell death
Heat shock protein 70 delays gentamicin-induced vestibular hair cell death
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DOI：
10.1080/00016480410017495-1
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发表时间：
2005-01
影响因子：
1.4
通讯作者：
M. Takumida;M. Anniko
中科院分区：
文献类型：
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作者：
M. Takumida;M. Anniko
香叶基香叶内酮(GGA)可诱导豚鼠前庭末梢器官热休克蛋白(HSP)70的表达，并减轻庆大霉素(GM)的耳毒性。这是在没有热预处理的情况下完成的。在分离的豚鼠前庭末梢器官中，我们证明了GGA可能通过主动诱导HSP70来预防(预防)GM耳毒性。GGA预先孵育HSP70后，感觉细胞胞浆和过渡性暗细胞中HSP70含量增加。用GGA预先孵育前庭末梢器官可以部分保护感觉细胞免受GM的毒性。这些结果表明，给予GGA可以保护前庭感觉细胞免受GM耳毒性的影响，并提示GGA诱导HSP70可能是治疗前庭疾病的有用辅助手段。
In this study, geranylgeranylacetone (GGA) was shown to induce heat shock protein (HSP)70 in the vestibular end organs of the guinea pig and to alleviate gentamicin (GM) ototoxicity. This was accomplished without thermal preconditioning. In isolated guinea pig vestibular end organs we demonstrated possible prophylactic (preventive) effects of GGA on GM ototoxicity by actively inducing HSP70. When HSP70 was pre-incubated with GGA, its content in sensory cell cytoplasm and transitional dark cells was increased. Pre-incubation of vestibular end organs with GGA gave sensory cells partial protection from GM toxicity. These findings show that administration of GGA can protect vestibular sensory cells from GM ototoxicity and suggest that induction of HSP70 by GGA may be a useful adjunct for the treatment of vestibular disorders.