Cancellous bone adaptation to tibial compression is not sex dependent in growing mice
Cancellous bone adaptation to tibial compression is not sex dependent in growing mice
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DOI：
10.1152/japplphysiol.00210.2010
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发表时间：
2010-09-01
影响因子：
3.3
通讯作者：
van der Meulen, Marjolein C. H.
中科院分区：
文献类型：
--
作者：
Lynch, Maureen E.;Main, Russell P.;van der Meulen, Marjolein C. H.
Lynch ME，Main RP，Xu Q，沃尔什DJ，Schaffler MB，Wright TM，货车der Meulen MC.生长期小鼠松质骨对胫骨压缩的适应性不具有性别依赖性。J Appl Physiol 109：685-691，2010.首次发表于2010年6月24日; doi：10.1152/japplphysiol.00210.2010。机械负荷可用于增加骨量，从而减轻病理性骨丢失。由于骨骼对负荷的适应性反应在成年前最为强烈，因此阐明生长期间的性别特异性反应可能有助于最大化峰值骨量。本研究调查了性别对生长期小鼠体内受控机械负荷反应的影响。对10周龄的雄性和雌性C57 Bl/6小鼠进行左胫骨的非侵入性压缩。施加的峰值载荷为-11.5 N，对应于两种性别胫骨中段的+1，200 mu载荷。通过显微计算机断层扫描和组织形态计量学比较了负载和对照肢体近端干骺端的松质骨质量、结构和动态形成。加载过程中的近端干骺端的应变环境的特点是使用有限元分析。两种性别对胫骨压缩的反应都是骨量增加和结构改变。通过骨小梁增厚和分离减少，两种性别的负载肢体的松质骨质量和组织密度相对于对照肢体均增强。质量的变化是由于与对照肢体相比，负荷肢体的细胞活性增加。对负荷的适应增加了近端干骺端松质骨转移负荷的比例。对于所有松质骨测量，雄性和雌性小鼠对胫骨压缩的反应没有差异。当在男性和女性中产生相似的应变时，松质骨对机械负荷的适应性反应不依赖于性别。
Lynch ME, Main RP, Xu Q, Walsh DJ, Schaffler MB, Wright TM, van der Meulen MC. Cancellous bone adaptation to tibial compression is not sex dependent in growing mice. J Appl Physiol 109: 685-691, 2010. First published June 24, 2010; doi: 10.1152/japplphysiol.00210.2010.-Mechanical loading can be used to increase bone mass and thus attenuate pathological bone loss. Because the skeleton's adaptive response to loading is most robust before adulthood, elucidating sex-specific responses during growth may help maximize peak bone mass. This study investigated the effect of sex on the response to controlled, in vivo mechanical loading in growing mice. Ten-week-old male and female C57Bl/6 mice underwent noninvasive compression of the left tibia. Peak loads of -11.5 N were applied, corresponding to +1,200 mu epsilon at the tibial midshaft in both sexes. Cancellous bone mass, architecture, and dynamic formation in the proximal metaphysis were compared between loaded and control limbs via micro-computed tomography and histomorphometry. The strain environment of the proximal metaphysis during loading was characterized using finite element analysis. Both sexes responded to tibial compression through increased bone mass and altered architecture. Cancellous bone mass and tissue density were enhanced in loaded limbs relative to control limbs in both sexes through trabecular thickening and reduced separation. Changes in mass were due to increased cellular activity in loaded limbs compared with control limbs. Adaptation to loading increased the proportion of load transferred by the cancellous bone in the proximal metaphysis. For all cancellous measures, the response to tibial compression did not differ between male and female mice. When similar strains are engendered in males and females, the adaptive response in cancellous bone to mechanical loading does not depend on sex.