Role of protease inhibitors in preventing recurrent oral candidosis in patients with HIV-infection: A prospective case-control study
Role of protease inhibitors in preventing recurrent oral candidosis in patients with HIV-infection: A prospective case-control study
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DOI：
10.1097/00126334-199905010-00003
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发表时间：
1999-05-01
期刊：
影响因子：
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通讯作者：
Cassone, A
中科院分区：
文献类型：
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作者：
Cauda, R;Tacconelli, E;Cassone, A
本研究旨在评估高效抗逆转录病毒治疗（HAART）在预防与HIV相关的口腔念珠菌病（OC）复发方面的疗效。一项前瞻性病例对照观察性研究在市中心大学医院的艾滋病毒/艾滋病诊所进行。将93例有复发性OC病史的hiv阳性研究对象分为两组：接受蛋白酶抑制剂（PI）治疗的患者（1组，n = 30）和未接受PI治疗的患者（2组，n = 63）。研究对象的性别、年龄、HIV感染阶段和外周血CD4(+) t细胞计数相匹配。非pi治疗组进一步细分为以下三个亚组：接受逆转录酶抑制剂治疗的hiv阳性研究受试者（RTI组；2a和2c组）和未接受RTI治疗的hiv阳性研究受试者（2b组）。2c组符合与2a组相同的纳入标准，但在研究开始6个月后进行匹配。我们还评估了体外外周血单个核细胞（PBMC）及其淋巴细胞增殖反应，以及皮肤延迟型超敏反应（DTH）对念珠菌相关抗原的反应，随机选择研究对象样本，分为接受PIs治疗和未接受PIs治疗的两组。在1年的随访中，接受pi治疗的2例（7%）和未接受pi治疗的23例（36%）被诊断为OC
This study was conducted to evaluate the efficacy of highly active antiretroviral therapy (HAART) in preventing recurrence of oral candidosis (OC) associated with HIV. A prospective case-controlled observational study was performed in an inner-city university-hospital HIV/AIDS clinic. Ninety-three HIV-positive study subjects with a history of recurrent OC were divided into two groups: protease inhibitors (PI)-treated patients (group 1, n = 30) and non-PI-treated patients (group 2, n = 63). Study subjects were matched for sex, age, stage of HIV infection, and peripheral CD4(+) T-cell counts. The non-PI-treated group was further subdivided into the following three subgroups: HIV-positive study subjects treated with reverse transcriptase inhibitors (RTI; groups 2a and 2c) and HIV-positive study subjects not treated with RTIs (group 2b). Group 2c met the same inclusion criteria as group 2a had but was matched 6 months after the beginning of the study. We also assessed in vitro peripheral blood mononuclear cells (PBMC) and their lymphoproliferative response, as well as cutaneous delayed-type hypersensitivity (DTH) response to Candida-associated antigens in a randomly selected sample of study subjects divided into those treated with PIs and those who were not. During a 1-year follow-up, OC was diagnosed in 2 (7%) PI-treated and 23 (36%) non-PI-treated patients (p