Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum.
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum.
复制标题
DOI：
10.1038/s41590-020-00826-9
复制
发表时间：
2021-01
影响因子：
30.5
通讯作者：
Farber DL
中科院分区：
文献类型：
--
作者：
Weisberg SP;Connors TJ;Zhu Y;Baldwin MR;Lin WH;Wontakal S;Szabo PA;Wells SB;Dogra P;Gray J;Idzikowski E;Stelitano D;Bovier FT;Davis-Porada J;Matsumoto R;Poon MML;Chait M;Mathieu C;Horvat B;Decimo D;Hudson KE;Zotti FD;Bitan ZC;La Carpia F;Ferrara SA;Mace E;Milner J;Moscona A;Hod E;Porotto M;Farber DL
新型冠状病毒SARS-CoV-2引起的COVID-19的临床表现与年龄相关。成人会出现呼吸道症状，最严重的情况可能会发展为急性呼吸窘迫综合征 (ARDS)，而儿童基本上不会出现呼吸道疾病，但可能会出现危及生命的多系统炎症综合征 (MIS-C)。在这里，我们展示了儿童和成人感染 SARS-CoV-2 后的不同抗体反应。成人 COVID-19 队列具有抗尖峰 (S) IgG、IgM 和 IgA 抗体，以及抗核衣壳 (N) IgG 抗体，而患有或不患有 MIS-C 的儿童的抗 SARS-CoV-2 特异性抗体的范围减少，主要产生针对 S 蛋白而不是 N 蛋白的 IgG 抗体。此外，与成人 COVID-19 队列相比，患有或未患有 MIS-C 的儿童的中和活性降低，表明保护性血清学反应降低。这些结果表明，无论儿童是否患有 MIS-C，儿童都有独特的感染过程和免疫反应，这对于制定针对年龄的测试和保护人群的策略具有重要意义。
Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age,. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C), –. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population.
登录
查看更多内容
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
影响因子：
64.5
作者：
Korber, Bette;Fischer, Will M.;Montefiori, David C.
通讯作者：
Montefiori, David C.
影响因子：
5.4
作者：
Cong, Yingying;Ulasli, Mustafa;Reggiori, Fulvio
通讯作者：
Reggiori, Fulvio
DOI：
10.1101/2020.04.15.20067157
发表时间：
2020-06-06
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cummings, Matthew J;Baldwin, Matthew R;O'Donnell, Max R
通讯作者：
O'Donnell, Max R
影响因子：
158.5
作者：
Feldstein, Leora R.;Rose, Erica B.;Randolph, Adrienne G.
通讯作者：
Randolph, Adrienne G.