Generation of oligopeptides with homochiral sequences by topochemical reactions within racemic crystals of phenylalanine-N-carboxyanhydride.
Generation of oligopeptides with homochiral sequences by topochemical reactions within racemic crystals of phenylalanine-N-carboxyanhydride.
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通过苯丙氨酸-N-羧酸酐外消旋晶体内的拓扑化学反应生成具有纯手性序列的寡肽。
DOI：
10.1002/anie.200351114
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发表时间：
2003
影响因子：
--
通讯作者：
M. Lahav
中科院分区：
文献类型：
--
作者：
J. G. Nery;G. Bolbach;I. Weissbuch;M. Lahav
晶体内的反应：通过利用固态下的”拉链样”机制（参见堆积图），从外消旋单体获得同手性寡聚（苯丙氨酸）（参见MALDI-TOF质谱）。通过在晶体结构内产生这样的物质，长度高达17个单位的寡肽的形成是合理的。
Reactions within crystals: Homochiral oligo (phenylalanine) s (see MALDI-TOF mass spectrum) were obtained from a racemic monomer by utilizing a" zipper-like" mechanism in the solid state (see packing diagram). By generating such species within crystalline architectures, the formation of oligopeptides of up to 17 units in length is plausible.