Cognition enhancement strategies.
Cognition enhancement strategies.
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DOI：
10.1523/jneurosci.4419-10.2010
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发表时间：
2010-11-10
期刊：
影响因子：
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通讯作者：
Alberini CM
中科院分区：
文献类型：
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作者：
Bibb JA;Mayford MR;Tsien JZ;Alberini CM
许多精神障碍、神经退行性和神经发育性疾病都涉及认知缺陷。显著的进步和新技术为认知的分子基础提供了更清晰的图景。结合SFN2010研讨会，我们简要概述了认知的分子机制，重点介绍了认知障碍治疗的发展。基因表达和蛋白质合成的活性依赖性变化与突触选择相结合，形成记忆回路。利用基因表达程序记录记忆回路形成的神经元活动依赖分子标记系统是研究认知的一种新工具。蛋白质翻译、蛋白质降解、细胞骨架动力学、细胞外基质相互作用、第二信使信号和神经递质受体运输和功能的调节都是认知所必需的突触重塑的组成部分。选择性靶向这些过程中的特定效应物，如NMDA受体，可能是治疗认知缺陷的有效策略。
Many mental disorders, and neurodegenerative and neurodevelopmental diseases involve cognitive deficits. Remarkable advances and new technologies are providing a clearer picture of the molecular basis of cognition. In conjunction with an SFN2010 symposium, we provided here a brief overview of the molecular mechanisms of cognition, with emphasis on the development of treatments for cognitive disorders. Activity-dependent changes in gene expression and protein synthesis integrate with synapse selection to form memory circuits. A neuronal activity-dependent molecular tagging system that utilizes the gene expression program to record memory circuit formation represents one new tool to study cognition. Regulation of protein translation, protein degradation, cytoskeletal dynamics, extracellular matrix interactions, second messenger signaling, and neurotransmitter receptor trafficking and function are all components of synaptic remodeling essential for cognition. Selective targeting of specific effectors in these processes, such as NMDA receptors, may serve as effective strategies to treat cognitive deficits.